Opis

• Tytuł:
  Substance P blockade effects on peripheral blood leukocytic reaction in secondary chronic inflammation
• Twórca:
  Shevchenko, O. M.;
  Sych, V. O.
• Opis:
  In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats. Compared with the natural course of inflammation, at 6 hours there was a significant decrease in total white blood cells count by 1.28 (p<0.05), as well as a significant decrease in the number of polymorphonuclear neutrophils by 4 times (p<0.05) and the number of eosinophils by 3 times (p<0.05) by 10 days. On day 28, there was a significant increase in the number of monocytes in 2 times (p<0,01). The results of the study indicate that in natural conditions of inflammation, substance P stimulates blood leukocytes, as well as prolongs the inflammatory response, and its blocking helps to reduce the inflammatory response.
• Dostępność obiektu:
  Dostęp otwarty
• Prawa:
  Prawa autorskie (c) 2019 © The Author (s)
• Data:
  2019.11.29
• Typ:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Język:
  angielski
• Źródło:
  Journal of Education, Health and Sport; Vol. 9 No. 11 (2019); 419-432;
  Journal of Education, Health and Sport; Tom 9 Nr 11 (2019); 419-432;
  2391-8306
• Format:
  application/pdf
• Wydawca:
  Nicolaus Copernicus University, Toruń, Poland
• Relacja: https://apcz.umk.pl/JEHS/article/view/JEHS.2019.09.11.039/27841
• Temat i słowa kluczowe:
  secondary chronic inflammation;
  peripheral blood;
  substance P;
  experiment;
  rats
• Identyfikator: https://apcz.umk.pl/JEHS/article/view/JEHS.2019.09.11.039
• Dostawca danych:
  Akademicka Platforma Czasopism
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