Description

• Title:
  Substance P blockade effects on peripheral blood leukocytic reaction in secondary chronic inflammation
• Creator:
  Shevchenko, O. M.;
  Sych, V. O.
• Description:
  In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats. Compared with the natural course of inflammation, at 6 hours there was a significant decrease in total white blood cells count by 1.28 (p<0.05), as well as a significant decrease in the number of polymorphonuclear neutrophils by 4 times (p<0.05) and the number of eosinophils by 3 times (p<0.05) by 10 days. On day 28, there was a significant increase in the number of monocytes in 2 times (p<0,01). The results of the study indicate that in natural conditions of inflammation, substance P stimulates blood leukocytes, as well as prolongs the inflammatory response, and its blocking helps to reduce the inflammatory response.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2019 © The Author (s)
• Date:
  2019.11.29
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 9 No. 11 (2019); 419-432;
  Journal of Education, Health and Sport; Tom 9 Nr 11 (2019); 419-432;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2019.09.11.039/27841
• Subject:
  secondary chronic inflammation;
  peripheral blood;
  substance P;
  experiment;
  rats
• Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2019.09.11.039
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text