Opis

• Tytuł:
  KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans
• Twórca:
  Dzikowska, Agnieszka;
  Grzelak, Anna;
  Gawlik, Joanna;
  Szewczyk, Edyta;
  Mrozek, Paweł;
  Borsuk, Piotr;
  Koper, Michał;
  Empel, Joanna;
  Szczesny, Pawel;
  Pękala, Małgorzata;
  Piłsyk, Sebastian;
  Węgleński, Piotr
• Opis:
  The kaeAKAE1 (suDpro) gene, which was identified in Aspergillus nidulans as a suppressor of proline auxotrophic mutations, encodes the orthologue of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex. In yeast, this complex has been shown to be involved in tRNA modification, transcription, and genome maintenance. In A. nidulans, mutations in kaeA result in several phenotypic effects, the derepression of arginine catabolism genes, and changes in the expression levels of several others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoATUP1, which encodes the global transcriptional corepressor.
• Dostępność obiektu:
  Dostęp otwarty
• Data:
  2015.12.01
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski
• Format:
  application/pdf
• Wydawca:
  Elsevier
• Relacja: http://eprints.ibb.waw.pl/978 ;http://www.journals.elsevier.com/gene ;doi:10.1016/j.gene.2015.07.066
• Temat i słowa kluczowe:
  Q Science (General);
  QR Microbiology
• Identyfikator: http://eprints.ibb.waw.pl/978/1/KaeA.pdf ;
  Dzikowska, Agnieszka and Grzelak, Anna and Gawlik, Joanna and Szewczyk, Edyta and Mrozek, Paweł and Borsuk, Piotr and Koper, Michał and Empel, Joanna and Szczesny, Pawel and Pękala, Małgorzata and Piłsyk, Sebastian and Węgleński, Piotr (2015) KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans. Gene, 573 (2). pp. 310-320. ISSN 0378-1119
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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