Object's details: KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans
Creator:
Dzikowska, Agnieszka;
Grzelak, Anna;
Gawlik, Joanna;
Szewczyk, Edyta;
Mrozek, Paweł;
Borsuk, Piotr;
Koper, Michał;
Empel, Joanna;
Szczesny, Pawel;
Pękala, Małgorzata;
Piłsyk, Sebastian;
Węgleński, Piotr
Description:
The kaeAKAE1 (suDpro) gene, which was identified in Aspergillus nidulans as a suppressor of proline auxotrophic mutations, encodes the orthologue of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex. In yeast, this complex has been shown to be involved in tRNA modification, transcription, and genome maintenance. In A. nidulans, mutations in kaeA result in several phenotypic effects, the derepression of arginine catabolism genes, and changes in the expression levels of several others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoATUP1, which encodes the global transcriptional corepressor.
Object availability:
free access
Date:
2015.12.01
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Publisher:
Elsevier
Relation: http://eprints.ibb.waw.pl/978 ;http://www.journals.elsevier.com/gene ;doi:10.1016/j.gene.2015.07.066
Subject:
Q Science (General);
QR Microbiology
Identifier: http://eprints.ibb.waw.pl/978/1/KaeA.pdf ;
Dzikowska, Agnieszka and Grzelak, Anna and Gawlik, Joanna and Szewczyk, Edyta and Mrozek, Paweł and Borsuk, Piotr and Koper, Michał and Empel, Joanna and Szczesny, Pawel and Pękala, Małgorzata and Piłsyk, Sebastian and Węgleński, Piotr (2015) KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans. Gene, 573 (2). pp. 310-320. ISSN 0378-1119
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans

Description

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