Object's details: Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro

Provider:Repozytorium Uniwersytetu Łódzkiego

Description

Title:
Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro
Creator:
Żołnierczyk, Jolanta;
Kaźmierczuk, Arleta;
Hikisz, Paweł;
Cebula-Obrzut, Barbara;
Wawrzyniak, Ewa;
Błoński, Jerzy Z.;
Misiewicz, Małgorzata;
Robak, Paweł;
Smolewski, Piotr;
Kiliańska, Zofia M.
Contributor:
Żołnierczyk Jolanta D., University of Łódź, Department of Cytobiochemistry, Faculty of Biology and Environmental Protection;
Kaźmierczuk, Arleta, University of Łódź, Department of Cytobiochemistry, Faculty of Biology and Environmental Protection;
Hikisz Paweł, University of Łódź, Department of Cytobiochemistry, Faculty of Biology and Environmental Protection;
Cebula-Obrzut Barbara, Medical University of Łódź, Department of Experimental Hematology,;
Wawrzyniak Ewa, Medical University of Łódź, Department of Hematology,;
Błoński Jerzy Z., Medical University of Łódź, Department of Hematology,;
Misiewicz Małgorzata , Medical University of Łódź, Department of Hematology,;
Robak Paweł, Medical University of Łódź, Department of Experimental Hematology;
Smolewski Piotr, Medical University of Łódź, Department of Experimental Hematology;
Kiliańska, Zofia M., University of Łódź, Department of Cytobiochemistry, Faculty of Biology and Environmental Protection;
zkilian@biol.uni.lodz.pl
Description:
It has been previously revealed that statins used at high concentrations display antileukemic potential towards chronic lymphocytic leukemia (CLL) cells. However, their usage alone in clinical practice may be limited due to possible side effects of high doses of these drugs. On the other hand, combined treatment of leukemia with statins and the conventional chemotherapeutics is questionable because of unknown influence of the first on the standard treatment results. This study has revealed that in vitro atorvastatin increases the proapoptotic potential of cladribine and mafosfamide in CLL cells isolated from peripheral blood of patients. Moreover, a preincubation with the above statin sensitizes leukemic cells to CM-induced apoptosis even at small concentrations of the drug. The usage of atorvastatin together with or followed by the conventional chemotherapy should be considered as therapeutic option for the treatment for this leukemia. Interestingly, CM-resistant patients might have the biggest benefits from atorvastatin administration.;
Grant no. 1407 from the University of Łódź.
Object availability:
free access
Rights:
Uznanie autorstwa 3.0 Polska;
http://creativecommons.org/licenses/by/3.0/pl
Date:
2015.06.12;
2015.03.05
Type:
Article
Language:
English
Format:
application/pdf
Publisher:
Hindawi Publishing Corporation
Relation:
Journal of Chemistry;Volume 2015 (2015)
Identifier:
2090-9071;
http://hdl.handle.net/11089/9501
Data provider:
Repozytorium Uniwersytetu Łódzkiego

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Object's details: Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro

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