Description

• Title:
  Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases
• Creator:
  Hikisz, Pawel;
  Jacenik, Damian
• Contributor:
  Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland;
  Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland;
  pawel.hikisz@biol.uni.lodz.pl
• Description:
  Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound involved in the pathogenesis of many diseases, including neurodegenerative diseases, cardiovascular and respiratory diseases, diabetes mellitus, and the development of cancers of various origins. In addition to environmental pollution (e.g., from car exhaust fumes) and tobacco smoke, a serious source of acrolein is our daily diet and improper thermal processing of animal and vegetable fats, carbohydrates, and amino acids. Dietary intake is one of the main routes of human exposure to acrolein, which is a major public health concern. This review focuses on the molecular mechanisms of acrolein activity in the context of its involvement in the pathogenesis of diseases related to the digestive system, including diabetes, alcoholic liver disease, and intestinal cancer.
• Object availability:
  free access
• Rights:
  Uznanie autorstwa 4.0 Międzynarodowe;
  http://creativecommons.org/licenses/by/4.0
• Date:
  2023.05.10;
  2023
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  MDPI
• Relation:
  International Journal of Molecular Sciences;24(7), 6579
• Subject:
  acrolein;
  diabetes;
  diet;
  diabetic retinopathy;
  diabetic nephropathy;
  alcoholic liver disease;
  colorectal cancer;
  oxidative stress;
  DNA adducts;
  α,β-unsaturated aldehydes
• Identifier:
  Hikisz Paweł, Jacenik Damian: Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases, International Journal of Molecular Sciences, Multidisciplinary Digital Publishing Institute (MDPI), vol. 24, nr 7, 2023, Numer artykułu: 6579, s. 1-23, DOI:10.3390/ijms24076579;
  1422-0067;
  http://hdl.handle.net/11089/47042 ;
  10.3390/ijms24076579
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  check license
• Type:
  image