Object's details: Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines

Provider:Repozytorium Uniwersytetu Łódzkiego

Description

Title:
Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines
Creator:
Grzelak, Agnieszka;
Krzyżanowski, Damian;
Kruszewski, Marcin
Contributor:
Department of Molecular Biophysics, University of Lodz, 90-237 Lodz, Poland;
Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, 91-738 Lodz, Poland; Laboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, Poland;
Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland; Department of Molecular Biology and Translational Research, Institute of Rural Health, 20-090 Lublin, Poland
Description:
Silver nanoparticles (AgNPs), due to their unique properties have been receiving immense attention in recent years. In addition to their antibacterial and antifungal activities, AgNPs also cause apoptosis, mitochondria disfunction, nucleic acid damage and show potent anticancer properties in both multidrug resistance (MDR) and sensitive tumors. The MDR phenomenon, caused by the presence of ATP-binding cassette (ABC) proteins, is responsible for the failure of chemotherapy. Thus, investigating the influence of widely used AgNPs on ABC transporters is crucial. In the present study, we have examined the cytotoxicity of silver nanoparticles of a nominal size of 20 nm (Ag20) on the cell lines of different tissue origins. In addition, we have checked the ATP-binding cassette transporters’ activity and expression under AgNP exposure. The results indicate that Ag20 shows a toxic effect on tested cells, as well as modulating the expression and transport activity of ABC proteins.
Object availability:
free access
Rights:
Uznanie autorstwa 4.0 Międzynarodowe;
http://creativecommons.org/licenses/by/4.0
Date:
2021.10.01;
2021
Type:
Article
Language:
English
Format:
application/pdf
Publisher:
MDPI
Relation:
Materials;14(12), 3383
Subject:
silver nanoparticles;
ABC transporters;
ATP-binding cassette;
multidrug resistance;
P-glycoprotein
Identifier:
Krzyzanowski, D.; Kruszewski, M.; Grzelak, A. Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines. Materials 2021, 14, 3383. https://doi.org/10.3390/ma14123383;
http://hdl.handle.net/11089/39305 ;
1996-1944;
10.3390/ma14123383
Data provider:
Repozytorium Uniwersytetu Łódzkiego

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Object's details: Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines

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