Object's details: Role of the PARP1/HPF1 complex in the conferring of resistance to doxorubicin in triple negative breast cancer (dataset)

Provider:Repozytorium Uniwersytetu Łódzkiego

Description

Title:
Role of the PARP1/HPF1 complex in the conferring of resistance to doxorubicin in triple negative breast cancer (dataset)
Creator:
Strachowska, Magdalena
Contributor:
Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska, Katedra Biofizyki Ogólnej;
magdalena.strachowska@biol.uni.lodz.pl
Description:
Data include results for ABC gene expression following: treatment with the PARP1 protein inhibitors Olaparib and Veliparib, silencing components of the PARP1/HPF1 complex, silencing of transcription factor - SMARCA1, treatment with antioxidants alone and in combination with Veliparib. Moreover, the collection is supplemented with data for ChIP-qPCR for the presence of SMARCA1 in PARP1-rich regions ABCC3, ABCC4 and ABCC5 and resazurin assay after silencing SMARCA1 protein in the combination with doxorubicin (1 µM) and paclitaxel (0.01 µM). The methodology of this work will be published with the manuscript.;
Narodowe Centrum Nauki, konkurs - Preludium 21 (numer projektu 2022/45/N/NZ5/01371)
Object availability:
free access
Rights:
Uznanie autorstwa 4.0 Międzynarodowe;
http://creativecommons.org/licenses/by/4.0
Date:
2025.03.26;
2023.02.15
Type:
Dataset
Language:
English
Format:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Subject:
multidrug resistance;
ABC transporters;
PARP1 inhibitors;
PARP1/HPF1 complex;
triple negative breast cancer;
doxorubicin resistance
Identifier: http://hdl.handle.net/11089/55091
Data provider:
Repozytorium Uniwersytetu Łódzkiego

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