Szczegóły obiektu: Understanding the Pathophysiology of Atopic Dermatitis – insights into Immune Dysregulation and Skin Barrier Dysfunction

Instytucja dostarczająca:Akademicka Platforma Czasopism

Opis

Title:
Understanding the Pathophysiology of Atopic Dermatitis – insights into Immune Dysregulation and Skin Barrier Dysfunction
Creator:
Maja Kucharska;
Kwiliński, Kacper;
Wawrzyńska, Barbara;
Cąkała, Marlena;
Kruszewski, Adrian;
Paduszyńska, Natalia;
Dąbrowska, Anna;
Przybysz, Paulina;
Szyszka, Monika
Description:
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a disrupted skin barrier and immune dysregulation. The exact pathophysiology of atopic dermatitis despite extensive research remains complex. It includes genetic disorders, a defect in the epidermal barrier, an altered immune response, and disruption of the skin’s microbial balance. Recent advances in research have provided deeper insights into the molecular mechanisms including the role of filaggrin mutations, Th2 cytokine-mediated inflammation, and the skin microbiome. Understanding the intricate interplay between these components is crucial for developing targeted therapeutic strategies. Aim of the study: This review provides a comprehensive overview of the current knowledge on the pathophysiological mechanisms underlying AD, highlighting recent advances and areas for future research. Material and methods: Comprehensive literature searches were performed across the main electronic databases of PubMed and GoogleScholar using the keywords: “atopic dermatitis”, “eczema pathophysiology”, “skin barrier”. Conclusions: Atopic dermatitis (AD) is a complex, chronic inflammatory skin disease with a multifaceted pathophysiology involving genetic, immunological, and environmental factors. Recent advances in understanding the molecular mechanisms underlying AD have highlighted the importance of skin barrier dysfunction, immune system dysregulation, and microbial interactions in the disease's progression.
Object availability:
Dostęp otwarty
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
Prawa autorskie (c) 2024 Maja Kucharska, Kacper Kwiliński, Barbara Wawrzyńska, Marlena Cąkała, Adrian Kruszewski, Natalia Paduszyńska, Anna Dąbrowska, Paulina Przybysz, Monika Szyszka
Date:
2024.08.31
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
angielski
Source:
Quality in Sport; Tom 19 (2024); 54073;
Quality in Sport; Vol. 19 (2024); 54073;
2450-3118
Format:
application/pdf
Publisher:
University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
Relation: https://apcz.umk.pl/QS/article/view/54073/39549
Subject:
atopic dermatitis;
eczema;
pathophysiology;
skin barrier;
skin microbiome
Identifier: https://apcz.umk.pl/QS/article/view/54073
Data provider:
Akademicka Platforma Czasopism

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