Szczegóły obiektu: Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk

Instytucja dostarczająca:Repozytorium Uniwersytetu Łódzkiego

Opis

Tytuł:
Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk
Twórca:
Forma, Ewa;
Wójcik-Krowiranda, Katarzyna;
Jóźwiak, Paweł;
Szymczyk, Agnieszka;
Bieńkiewicz, Andrzej;
Bryś, Magdalena;
Krześlak, Anna
Współtwórca:
University of Łódź, Department of Cytobiochemistry;
Medical University of Łódź, Clinical Division of Gynecological Oncology;
zreg@biol.uni.lodz.pl
Opis:
TopBP1 (topoisomerase IIβ binding protein 1) protein is involved in DNA replication, DNA damage checkpoint response and transcriptional regulation. In this study we investigated whether alterations in the TopBP1 gene can influence the risk of endometrial cancer. We examined the association between five single nucleotide polymorphisms (rs185903567, rs116645643, rs115160714, rs116195487, and rs112843513) located in the 3′UTR region of the TopBP1 gene and endometrial cancer risk as well as allele-specific gene expression. One hundred twenty-one endometrial cancer patients were genotyped for these SNPs. Allele-specific TopBP1 mRNA and protein expressions were determined by real time PCR and western blotting methods, respectively. Only one SNP (rs115160714) showed an association with endometrial cancer. Compared to homozygous common allele carriers, heterozygous for the T variant had significantly increased risk of endometrial cancer [adjusted odds ratio (OR) = 5.59, 95 % confidence interval (CI): 1.96–15.91, p = 0.0003]. Mean TopBP1 mRNA and protein expression were higher in the individuals with the CT genotype. There was a significant association between the rs115160714 and tumor grade and FIGO classification. Most carriers of minor allele had a high grade tumors (G3) classified as FIGO III/IV. The results of our study raise a possibility that a genetic variation of TopBP1 may be implicated in the etiology of endometrial cancer.
Dostępność obiektu:
Dostęp otwarty
Prawa:
Uznanie autorstwa 3.0 Polska;
http://creativecommons.org/licenses/by/3.0/pl
Data:
2016.04.01;
2013
Typ:
Article
Język:
angielski
Format:
application/pdf
Wydawca:
Springer Netherlands
Relacja:
Pathology & Oncology Research;3;
20
Temat i słowa kluczowe:
Topoisomerase IIβ binding protein 1;
Polymorphism;
Genetic variation;
Endometrial cancer
Identyfikator:
1219-4956;
http://hdl.handle.net/11089/17655 ;
1532-2807;
10.1007/s12253-013-9737-7
Dostawca danych:
Repozytorium Uniwersytetu Łódzkiego

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Szczegóły obiektu: Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk

Opis

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