Object's details: Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk

Provider:Repozytorium Uniwersytetu Łódzkiego

Description

Title:
Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk
Creator:
Forma, Ewa;
Wójcik-Krowiranda, Katarzyna;
Jóźwiak, Paweł;
Szymczyk, Agnieszka;
Bieńkiewicz, Andrzej;
Bryś, Magdalena;
Krześlak, Anna
Contributor:
University of Łódź, Department of Cytobiochemistry;
Medical University of Łódź, Clinical Division of Gynecological Oncology;
zreg@biol.uni.lodz.pl
Description:
TopBP1 (topoisomerase IIβ binding protein 1) protein is involved in DNA replication, DNA damage checkpoint response and transcriptional regulation. In this study we investigated whether alterations in the TopBP1 gene can influence the risk of endometrial cancer. We examined the association between five single nucleotide polymorphisms (rs185903567, rs116645643, rs115160714, rs116195487, and rs112843513) located in the 3′UTR region of the TopBP1 gene and endometrial cancer risk as well as allele-specific gene expression. One hundred twenty-one endometrial cancer patients were genotyped for these SNPs. Allele-specific TopBP1 mRNA and protein expressions were determined by real time PCR and western blotting methods, respectively. Only one SNP (rs115160714) showed an association with endometrial cancer. Compared to homozygous common allele carriers, heterozygous for the T variant had significantly increased risk of endometrial cancer [adjusted odds ratio (OR) = 5.59, 95 % confidence interval (CI): 1.96–15.91, p = 0.0003]. Mean TopBP1 mRNA and protein expression were higher in the individuals with the CT genotype. There was a significant association between the rs115160714 and tumor grade and FIGO classification. Most carriers of minor allele had a high grade tumors (G3) classified as FIGO III/IV. The results of our study raise a possibility that a genetic variation of TopBP1 may be implicated in the etiology of endometrial cancer.
Object availability:
free access
Rights:
Uznanie autorstwa 3.0 Polska;
http://creativecommons.org/licenses/by/3.0/pl
Date:
2016.04.01;
2013
Type:
Article
Language:
English
Format:
application/pdf
Publisher:
Springer Netherlands
Relation:
Pathology & Oncology Research;3;
20
Subject:
Topoisomerase IIβ binding protein 1;
Polymorphism;
Genetic variation;
Endometrial cancer
Identifier:
1219-4956;
http://hdl.handle.net/11089/17655 ;
1532-2807;
10.1007/s12253-013-9737-7
Data provider:
Repozytorium Uniwersytetu Łódzkiego

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Object's details: Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk

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