Description

• Tytuł:
  cis-Urocanic acid as a potential nickel(ii) binding molecule in the human skin
• Twórca:
  Wezynfeld, Nina Ewa;
  Goch, Wojciech;
  Bal, Wojciech;
  Frączyk, Tomasz
• Opis:
  cis-Urocanic acid, a derivative of histidine, is one of the essential components of human skin. We found that it can bind nickel(II) ions in a pH-dependent manner, with the dissociation constant in the low millimolar range, as revealed by potentiometry, and confirmed by isothermal titration calorimetry and UV-vis spectroscopy. The binding occurs within the physiological skin pH range. Considering the fact that cis-urocanic acid is present in the human skin in concentrations as high as millimolar, this molecule may be a physiologically important player in nickel trafficking in the human organism.
• Dostępność obiektu:
  free access
• Data:
  2014
• Typ:
  Article;
  PeerReviewed
• Język:
  English
• Format:
  application/pdf
• Relacja: http://eprints.ibb.waw.pl/775 ;http://dx.doi.org/10.1039/c3dt53194e ;doi:10.1039/c3dt53194e
• Temat i słowa kluczowe:
  QD Chemistry;
  QH301 Biology;
  QP Physiology;
  RL Dermatology
• Identyfikator: http://eprints.ibb.waw.pl/775/1/cis-Urocanic_Acid_paper_rev_repository.pdf ;
  Wezynfeld, Nina Ewa and Goch, Wojciech and Bal, Wojciech and Frączyk, Tomasz (2014) cis-Urocanic acid as a potential nickel(ii) binding molecule in the human skin. Dalton Transactions, 43 (8). pp. 3196-3201. ISSN 1477-9226
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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