Object's details: Metal assisted peptide bond hydrolysis: Chemistry, biotechnology and toxicological implications

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Metal assisted peptide bond hydrolysis: Chemistry, biotechnology and toxicological implications
Creator:
Wezynfeld, Nina Ewa;
Frączyk, Tomasz;
Bal, Wojciech
Description:
Metal-assisted hydrolysis of peptide bond is a promising alternative for enzymatic cleavage of proteins with prospective applications in biochemistry and bioengineering. Many metal ions and complexes have been tested for such reactivity with a number of targets, from dipeptides through oligopeptides through proteins. The majority of reaction mechanisms reported so far is based on the Lewis acidity of a given metal ion. In the alternative hydrolysis reaction the metal ion, Cu(II), Ni(II) or Pd(II), plays a structural role by forming a square planar complex with Ser/Thr–His or Ser/Thr–Xaa–His sequence, which enables a N → O rearrangement of the acyl moiety in the peptide bond downstream from the Ser/Thr residue. Both Lewis acid and N → O acyl rearrangement reaction types are discussed in detail, including molecular mechanisms, the chemical character of hydrolytic agents, reaction conditions, and the origins of differences between the results obtained for peptide and protein models. Toxicological implications and practical applications of metal assisted peptide bond hydrolysis are also presented, with a focus on the Ni(II) assisted N → O acyl rearrangement in Ser/Thr–Xaa–His sequences.
Object availability:
free access
Date:
2016.03
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Publisher:
Elsevier
Relation: http://eprints.ibb.waw.pl/1188 ;http://www.sciencedirect.com/science/article/pii/S0010854516300169 ;
10.1016/j.ccr.2016.02.009
Subject:
QD Chemistry;
QH301 Biology;
RB Pathology
Identifier: http://eprints.ibb.waw.pl/1188/1/1-s2.0-S0010854516300169-main.pdf ;
Wezynfeld, Nina Ewa and Frączyk, Tomasz and Bal, Wojciech (2016) Metal assisted peptide bond hydrolysis: Chemistry, biotechnology and toxicological implications. Coordination Chemistry Reviews . ISSN 0010-8545 (In Press)
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Metal assisted peptide bond hydrolysis: Chemistry, biotechnology and toxicological implications

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