Opis

• Tytuł:
  A minimal Fanconi Anemia complex in early diverging fungi
• Twórca:
  Barua, Drishtee;
  Płecha, Magdalena;
  Muszewska, Anna
• Opis:
  anconi Anemia (FA) pathway resolves DNA interstrand cross links (ICL). The FA pathway was initially recognized in vertebrates, but was later confirmed in other animals and speculated in fungi. FA proteins FANCM, FANCL and FANCJ are present in Saccharomyces cerevisiae but, their mechanism of interaction to resolve ICL is still unclear. Unlike Dikarya, early diverging fungi (EDF) possess more traits shared with animals. We traced the evolutionary history of the FA pathway across Opisthokonta. We scanned complete proteomes for FA-related homologs to establish their taxonomic distribution and analyzed their phylogenetic trees. We checked transcription profiles of FA genes to test if they respond to environmental conditions and their genomic localizations for potential co-localization. We identified fungal homologs of the activation and ID complexes, 5 out of 8 core proteins, all of the endonucleases, and deubiquitination proteins. All fungi lack FANCC, FANCF and FANCG proteins responsible for post-replication repair and chromosome stability in animals. The observed taxonomic distribution can be attributed to a gradual degradation of the FA pathway from EDF to Dikarya. One of the key differences is that EDF have the ID complex recruiting endonucleases to the site of ICL. Moreover, 21 out of 32 identified FA genes are upregulated in response to different growth conditions. Several FA genes are co-localized in fungal genomes which also could facilitate co-expression. Our results indicate that a minimal FA pathway might still be functional in Mucoromycota with a gradual loss of components in Dikarya ancestors.
• Dostępność obiektu:
  Dostęp otwarty
• Data:
  2024.04.30
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski
• Format:
  application/pdf
• Relacja: http://eprints.ibb.waw.pl/2386 ;https://www.nature.com/articles/s41598-024-60318-w ;
  10.1038/s41598-024-60318-w
• Temat i słowa kluczowe:
  QH301 Biology;
  QR Microbiology
• Identyfikator: http://eprints.ibb.waw.pl/2386/1/Barua_et_al-2024-Scientific_Reports.pdf ;
  Barua, Drishtee and Płecha, Magdalena and Muszewska, Anna (2024) A minimal Fanconi Anemia complex in early diverging fungi. Scientific Reports . ISSN 2045-2322
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
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