Opis

• Tytuł:
  Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis
• Twórca:
  Kuchma, Igor;
  Korda, Mykhaylo;
  Klishch, Mykola;
  Popovych, Dariya;
  Żukow, Xawery;
  Popovych, Igor
• Description:
  Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects in healthy rats and humans as well as patients with dysfunction of neuroendocrine-immune complex, encephalopatia and chronic pyelonephritis. The purpose of this study is clarification of the role of neuro-endocrine factors in their immunotropic activity in patients with chronic pyelonephritis. Materials and Methods. The object of observation were 17 men (aged 24-70 years) with chronic pyelonephritis in remission. The plasma levels and urinary excretion of nitrogenous metabolites as well as parameters of immunity and its neuro-endocrine regulation twice (on admission and after balneotherapy at the Truskavets’ Spa) was performed. Results. Judging by the multiple correlation coefficient, uricosuria exhibits maximal neuro-endocrine activity (R=0,780), followed by bilirubinemia (R=0,742), creatinineuria (R=0,692), uricemia (R=0,636), creatinineemia (R=0,632), urea excretion (R=0,536), instead urea plasma correlate with neuro-endocrine parameters insignificantly (R=0,360). Nitrogenous metabolites together determine the state of neuro-endocrine regulation by 94,2%, which, in turn, determine the state of immunity by 99,9%. Conclusion. Nitrogenous metabolites carry out immunomodulation in different ways: directly through aryl hydrocarbon (bilirubin), toll-like and adenosine (uric acid) receptors of immunocytes; through modulation of the activity of neurons of the autonomous nervous system and endocrinocytes with subsequent neuro-endocrine immunomodulation; and also, apparently, due to an off-receptor effect on neurons, endocrinocytes and immunocytes (urea and creatinine).
• Object availability:
  Dostęp otwarty
• Rights:
  Prawa autorskie (c) 2022 Igor Kuchma, Mykhaylo Korda, Mykola Klishch, Dariya Popovych, Xawery Żukow, Igor Popovych;
  http://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2022.05.31
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  angielski
• Source:
  Journal of Education, Health and Sport; Vol. 12 No. 5 (2022); 362-385;
  Journal of Education, Health and Sport; Tom 12 Nr 5 (2022); 362-385;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/39817/33162
• Subject:
  bilirubin;
  uric acid;
  urea;
  creatinine;
  immunity;
  HRV;
  adaptation hormones;
  relationships;
  chronic pyelonephritis
• Identifier: https://apcz.umk.pl/JEHS/article/view/39817
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  poproś o pozwolenie
• Type:
  teksty