Szczegóły obiektu: The role of lipid peroxidation and antioxidant protection in skin in the development of experimental contact dermatitis

Instytucja dostarczająca:Akademicka Platforma Czasopism

Opis

Title:
The role of lipid peroxidation and antioxidant protection in skin in the development of experimental contact dermatitis
Creator:
Regeda-Furdychko, M. M.
Description:
The purpose of work to study the conditions of prooxidant andantioxidant system in the skin of guinea pigs in different periods of contact dermatitis formation.Materials and methods. Researches were conducted on guinea pigs, divided into five groups: I - control, II – 4th day of expirement, III – 8th day of contact dermatitis development, IV – 10th day and V - 18 th day of model process. Early period included groups of animals on the 4th and 8th days of experiment. The late one – guinea pigs on the 10th and 18th days of contact dermatitis. Experimental contact dermatitis was simulated by method of Volkovoj V. A. (2010). Condition of free radical lipid oxidization in the skin was determined on maintenance content of malonic dialdehyde by method of Corobeynikov E. G. (1989) and diene conjugates by method of Gavrylov V. G., Myshkorudna M. I. (1989). The degree of activity of antioxidant defence was estimated on maintenance enzymes - superoxidedismutase by method of R. Fried (1975), catalase by the method of B. Holmes, C. Masters (1970), glutationperoxidase method of Arkhipova O. G. (1988) and glutationreductase method of Moina V. M. (1986).Results and discussion. Gradual increasing of lipid peroxydations products - malonic dialdehyde, diene conjugate had been determined on the 4th, 8th, 10th and 18th days of experimental contact dermatitis development in this research. Primary increasing of the indices of superoxidedismutase, glutationreductase, glutationperoxidase and catalase has been investigated in the skin on the 4th day with the following decreasing of these enzymes from the 8th day of experiment. It testified about imbalance in antioxidant and prooxydant systems, especially on the 10th and 18th days of the study, which exacerbates the inflammatory process in the skin and also triggers a cascade of other mechanisms of damage.
Object availability:
Dostęp otwarty
Rights:
Prawa autorskie (c) 2020 © The Author (s)
Date:
2020.12.11
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
angielski
Source:
Journal of Education, Health and Sport; Vol. 10 No. 12 (2020); 56-64;
Journal of Education, Health and Sport; Tom 10 Nr 12 (2020); 56-64;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.12.006/27410
Subject:
contact dermatitis;
malonic dialdehyde;
diene conjugate;
superoxidedismutase;
catalase;
glutationperoxidase;
glutationreductase
Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.12.006
Data provider:
Akademicka Platforma Czasopism

Podobne obiekty

The role of lipid peroxidation and antioxidant protection in skin in the development of experimental contact dermatitis

Twórca:Regeda-Furdychko, M. M.

Data:2020.12.11

Rodzaj zawartości:teksty

Evaluation of the influence of thiotriazoline on the cytokine status disturbances in the blood serum under the condition of experimental contact dermatitis and experimental pneumonia

Twórca:Regeda-Furdychko, M. M.

Data:2020.01.14

Rodzaj zawartości:teksty

The level of endogenic intoxication in the dynamics of development of experimental contact dermatitis and experimental pneumonia and their correction by thiotriazoline

Twórca:Regeda-Furdychko, M. M.

Data:2019.11.29

Rodzaj zawartości:teksty

The effect of thiotriazoline on impaired immune system in experimental pneumonia and contact dermatitis

Twórca:Regeda-Furdychko, M. M.

Data:2019.12.28

Rodzaj zawartości:teksty

The influence of thiotriazoline on the indicators of nitric oxide under the condition of experimental contact dermatitis and experimental pneumonia

Twórca:Regeda-Furdychko, M. M.

Data:2020.02.04

Rodzaj zawartości:teksty

The role of lipid peroxidation in the pathogenesis of experimental peritonitis

Twórca:Savytskyi, I. V. | Znamerovsky, S. G. | Dzygal, O. F. | Moiseieva, G. | Yermuraki, P.

Data:2020.07.31

Rodzaj zawartości:teksty

Pathogenetic substantiation of thiotriazoline use on the basis of disorders of proteolysis processes and protease inhibitors under conditions of contact dermatitis and experimental pneumonia

Twórca:Regeda-Furdychko, M. M.

Data:2019.06.28

Rodzaj zawartości:teksty

Characteristic of individual indicators of phagocytic activity of leukocytes under conditions of formation of experimental contact dermatitis and experimental pneumonia and the effect of the drug thiotriazoline

Twórca:Regeda-Furdychko, M. M.

Data:2019.10.30

Rodzaj zawartości:teksty

Federacja Bibliotek Cyfrowych

Szczegóły obiektu: The role of lipid peroxidation and antioxidant protection in skin in the development of experimental contact dermatitis

Opis

Podobne obiekty