Opis

• Tytuł:
  Modulation of Inflammation in Heart Failure: The Role of Ziltivekimab and Canakinumab
• Twórca:
  Wołowiec, Łukasz;
  Zukow, Walery;
  Pęcherz, Julia;
  Czaplińska, Daria;
  Jaśniak, Albert;
  Grześk, Grzegorz
• Opis:
  This article examines the role of inflammation in heart failure pathogenesis and explores novel therapeutic strategies targeting inflammatory pathways. The increasing prevalence of heart failure, particularly those with preserved ejection fraction (HFpEF), highlights the urgent demand for effective treatments. Canakinumab, a monoclonal antibody targeting interleukin-1β, has shown promise in reducing cardiovascular events by modulating inflammation, while Ziltivekimab, a newer monoclonal antibody targeting interleukin-6, demonstrates potential in heart failure patients with elevated inflammatory markers. The article reviews clinical trials, including CANTOS and RESCUE, providing evidence of the efficacy of patient outcomes. The findings underscore the importance of personalized treatment strategies on heart failure, with a focus on inflammation-driven pathways, positioning anti-inflammatory therapies as a significant advancement in cardiovascular disease management. Future research will determine the broader clinical applicability of these therapies in managing heart failure, its complications, and fostering more favorable outcomes.
• Dostępność obiektu:
  Dostęp otwarty
• Prawa:
  Prawa autorskie (c) 2024 Łukasz Wołowiec, Walery Zukow, Julia Pęcherz, Daria Czaplińska, Albert Jaśniak, Grzegorz Grześk;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Data:
  2024.10.09
• Typ:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Język:
  angielski
• Źródło:
  Journal of Education, Health and Sport; Vol. 65 (2024); 55579;
  Journal of Education, Health and Sport; Tom 65 (2024); 55579;
  2391-8306
• Format:
  application/pdf
• Wydawca:
  Nicolaus Copernicus University, Toruń, Poland
• Relacja: https://apcz.umk.pl/JEHS/article/view/55579/39985
• Temat i słowa kluczowe:
  ziltivekimab;
  canakinumab;
  heart failure
• Identyfikator: https://apcz.umk.pl/JEHS/article/view/55579
• Dostawca danych:
  Akademicka Platforma Czasopism
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