Opis

• Tytuł:
  GLP-1 analogs in the treatment of obesity
• Twórca:
  Metelska, Aleksandra;
  Metelski, Jakub;
  Sereda, Dominika;
  Nieścior, Hubert
• Opis:
  Introduction and purpose Obesity is a chronic disease that causes the development of numerous complications such as cardiovascular disease, cancer and type 2 diabetes. The 2017 global nutrition report showed that 2 billion adults and 41 million children worldwide are overweight or obese. Due to the growing problem of obesity, pharmacotherapy is recommended in patients with BMI ≥30 kg / m2 or BMI> 27 kg / m2 with accompanying risk factors. The aim of the study is to discuss the role of GLP-1 analogues in the treatment of obesity. Description of the state of knowledge  GLP-1 receptor agonists that were initially related to the treatment of type 2 diabetes are now being used successfully in the treatment of obesity. The GLP-1 hormone is released from intestinal enteroendocrine cells in response to an increase in glucose levels. Due to the wide neuroanatomical distribution of GLP-1R within the structures of the reward system, it is possible to suppress the need for food intake, which translates into a reduction in the amount of food consumed and a decrease in body weight. The most common side effects associated with the use of GLP-1 analogues include gastrointestinal symptoms such as nausea, vomiting, diarrhea and constipation, which rarely lead to discontinuation of treatment. Summary Numerous studies have shown that chronic systemic delivery of GLP-1 agonists led to weight loss and helped to maintain a lower body weight. Reduction in food intake is reported as the main mechanism. Discontinuation of the drug was associated with weight gain.
• Dostępność obiektu:
  Dostęp otwarty
• Prawa:
  Prawa autorskie (c) 2022 Aleksandra Metelska, Jakub Metelski, Dominika Sereda, Hubert Nieścior;
  http://creativecommons.org/licenses/by-nc-sa/4.0
• Data:
  2022.08.06
• Typ:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Język:
  angielski
• Źródło:
  Journal of Education, Health and Sport; Vol. 12 No. 8 (2022); 334-342;
  Journal of Education, Health and Sport; Tom 12 Nr 8 (2022); 334-342;
  2391-8306
• Format:
  application/pdf
• Wydawca:
  Nicolaus Copernicus University, Toruń, Poland
• Relacja: https://apcz.umk.pl/JEHS/article/view/39318/32910
• Temat i słowa kluczowe:
  glucagon-like peptide-1;
  obesity;
  GLP-1 receptor expression;
  GLP-1R driven food-oriented behaviors
• Identyfikator: https://apcz.umk.pl/JEHS/article/view/39318
• Dostawca danych:
  Akademicka Platforma Czasopism
• Czy mogę z tego obiektu skorzystać?:
  poproś o pozwolenie
• Rodzaj zawartości:
  teksty