Szczegóły obiektu: Hif-1α and IGF Expression in Endometrial Hyperplasia

Instytucja dostarczająca:Akademicka Platforma Czasopism

Opis

Tytuł:
Hif-1α and IGF Expression in Endometrial Hyperplasia
Twórca:
Chumak, Z. V.;
Shapoval, M. V.;
Andrievskiy, O. G.
Opis:
The objective: to assess the effect of insulin resistance and hypoxia on the risk of endometrial hyperplasia development. The research was conducted on the base of Municipal Maternity House №5 (Odessa, Ukraine). The data obtained from the sample of 417 reproductive, perimenopausal, and postmenopausal age women who referred for medical care to the gynecological department, were analyzed. All the women under examination were carried out medical and diagnostic scraping of the uterine cavity. Results. The intensity of hypoxia increases with age and closely correlates (r=0,78) with the level of insulin resistance. IGF demonstrates reverse dynamics – its rates has been diminished with age (r=-0,63). Conclusion. It was demonstrated that insulin resistance and hypoxia play significant role in the pathogenesis of endometrial hyperplasia. Indices of IGF and HIF could be recommended as valuable biomarkers of prognosis in the case of endometrial hyperplasia.
Dostępność obiektu:
Dostęp otwarty
Prawa:
Prawa autorskie (c) 2020 © The Author (s)
Data:
2020.11.11
Typ:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Język:
angielski
Źródło:
Journal of Education, Health and Sport; Vol. 10 No. 11 (2020); 61-68;
Journal of Education, Health and Sport; Tom 10 Nr 11 (2020); 61-68;
2391-8306
Format:
application/pdf
Wydawca:
Nicolaus Copernicus University, Toruń, Poland
Relacja: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.11.006/27002
Temat i słowa kluczowe:
endometrial hyperplasia;
IGF;
Hif-1α;
malignancy
Identyfikator: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.11.006
Dostawca danych:
Akademicka Platforma Czasopism

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Szczegóły obiektu: Hif-1α and IGF Expression in Endometrial Hyperplasia

Opis

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