Opis

• Tytuł:
  Transcription termination factor Rho: a hub linking diverse physiological processes in bacteria.
• Twórca:
  Grylak-Mielnicka, Aleksandra;
  Bidnenko, Vladimir;
  Bardowski, Jacek K.;
  Bidnenko, Elena
• Opis:
  Factor-dependent termination of transcription in bacteria relies on the activity of a specific RNA helicase, the termination factor Rho. Rho is nearly ubiquitous in bacteria, but the extent to which its physiological functions are conserved throughout the different phyla remains unknown. Most of our current knowledge concerning the mechanism of Rho's activity and its physiological roles comes from the model micro-organism Escherichia coli, where Rho is essential and involved in the control of several important biological processes. However, the rather comprehensive knowledge about the general mechanisms of action and activities of Rho based on the E. coli paradigm cannot be directly extrapolated to other bacteria. Recent studies performed in different species favour the view that Rho-dependent termination plays a significant role even in bacteria where Rho is not essential. Here, we summarize the current state of the ever-increasing knowledge about the various aspects of the physiological functions of Rho, such as limitation of deleterious foreign DNA expression, control of gene expression, suppression of pervasive transcription, prevention of R-loops and maintenance of chromosome integrity, focusing on similarities and differences of the activities of Rho in various bacterial species.
• Dostępność obiektu:
  Dostęp otwarty
• Data:
  2016.02
• Typ:
  Article;
  PeerReviewed
• Język:
  angielski
• Format:
  application/pdf
• Relacja: http://eprints.ibb.waw.pl/1158
• Temat i słowa kluczowe:
  QR Microbiology
• Identyfikator: http://eprints.ibb.waw.pl/1158/1/agm.pdf ;
  Grylak-Mielnicka, Aleksandra and Bidnenko, Vladimir and Bardowski, Jacek K. and Bidnenko, Elena (2016) Transcription termination factor Rho: a hub linking diverse physiological processes in bacteria. Microbiology (Reading, England), 162 (3). pp. 433-47. ISSN 1465-2080
• Dostawca danych:
  Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk
• Czy mogę z tego obiektu skorzystać?:
  poproś o pozwolenie
• Rodzaj zawartości:
  pozostałe