Description

• Title:
  The artificial oxygen carrier erythrocruorin—characteristics and potential significance in medicine
• Creator:
  Kruczkowska, Weronika;
  Kciuk, Mateusz;
  Pasieka, Zbigniew;
  Kłosiński, Karol;
  Płuciennik, Elżbieta;
  Elmer, Jacob;
  Waszczykowska, Klaudia;
  Kołat, Damian;
  Kałuzińska-Kołat, Żaneta
• Contributor:
  Faculty of Biomedical Sciences, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Poland;
  Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland; Doctoral School of Exact and Natural Sciences, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland;
  Department of Experimental Surgery, Medical University of Lodz, Narutowicza 60, 90-136, Lodz, Poland;
  Department of Functional Genomics, Medical University of Lodz, Zeligowskiego 7/9, 90-752, Lodz, Poland;
  Department of Chemical and Biological Engineering, Villanova University, Villanova, PA, USA
• Description:
  The diminishing supply and increasing costs of donated blood have motivated research into novel hemoglobin-based oxygen carriers (HBOCs) that can serve as red blood cell (RBC) substitutes. HBOCs are versatile agents that can be used in the treatment of hemorrhagic shock. However, many of the RBC substitutes that are based on mammalian hemoglobins have presented key limitations such as instability and toxicity. In contrast, erythrocruorins (Ecs) are other types of HBOCs that may not suffer these disadvantages. Ecs are giant metalloproteins found in annelids, crustaceans, and some other invertebrates. Thus far, the Ecs of Lumbricus terrestris (LtEc) and Arenicola marina (AmEc) are the most thoroughly studied. Based on data from preclinical transfusion studies, it was found that these compounds not only efficiently transport oxygen and have anti-inflammatory properties, but also can be modified to further increase their effectiveness. This literature review focuses on the structure, properties, and application of Ecs, as well as their advantages over other HBOCs. Development of methods for both the stabilization and purification of erythrocruorin could confer to enhanced access to artificial blood resources.
• Object availability:
  free access
• Rights:
  Uznanie autorstwa 4.0 Międzynarodowe;
  http://creativecommons.org/licenses/by/4.0
• Date:
  2023.08.10;
  2023
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  Springer Nature
• Relation:
  Journal of Molecular Medicine;101
• Subject:
  Erythrocruorin;
  Hemoglobin;
  Artificial oxygen carriers;
  Red blood cell substitutes
• Identifier:
  Kruczkowska Weronika, Kciuk Mateusz, Pasieka Zbigniew, Kłosiński Karol, Płuciennik Elżbieta, Elmer Jacob, Waszczykowska Klaudia, Kołat Damian, Kałuzińska-Kołat Żaneta: The artificial oxygen carrier erythrocruorin— characteristics and potential significance in medicine, Journal of Molecular Medicine-Jmm, vol. 101, nr 8, 2023, s. 961-972, DOI:10.1007/s00109-023- 02350-3;
  0946-2716;
  http://hdl.handle.net/11089/47769 ;
  1432-1440;
  10.1007/s00109-023-02350-3
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  check license
• Type:
  image