Description

• Title:
  Intracardiac hemodynemics, fibroblast growth factor-2 and oxyproline levels with mitral valve prolapse in combination with type 1 diabetes mellitus
• Creator:
  Nikolenko, Olena;
  Korzh, Oleksii
• Description:
  The purpose. The aim of the study was a comparative analysis of basic echocardiographic parameters, fibroblast growth factor-2 and free and peptide-bounding oxyproline indicators in young patients with mitral valve prolapse, type 1 diabetes mellitus and the combination of both indications.Materials and methods. 93 patients between 19 and 33 years old with either mitral valve prolapse, type 1 diabetes and the combination of both indications were examined.  There are 24 people with diagnosed mitral valve prolapse, 33 patients with type 1 diabetes mellitus and mitral valve prolapse and 36 patients with the monomorbid type 1 diabetes mellitus. The establishment of the diagnosis of mitral valve prolapse implemented by echocardiographic criteria L. Freed et al. (2002). The concentration of fibroblast growth factor-2 in blood plasma was determined by the enzyme immunoassay using a Quantikine reagent kit (Human FGF basic Immunoassay), manufactured by R&D Systems, Inc. (USA) and expressed in pg/ml. Free and peptide-bounding oxyproline as the markers of connective tissue metabolism were determined by the method of P. N. Sharaev and expressed in µmol/L.Results. In patients with mitral valve prolapse and ype 1 diabetes mellitus, the higher values of l left ventricular posterior wall thickness and intraventricular septum have been revealed in comparison with the groups of patients with monomorbid mitral valve prolapse and ype 1 diabetes mellitus. Fibroblast growth factor-2 was higher in group with combination of both indications, where it was [23.7 ± 0.25] pg/ml compared to the control group [14.20 ± 0.22] pg/ml (p <0.01). There was also a significant difference in the levels of fibroblast growth factor-2 between group with either mitral valve prolapse [15.33 ±0.24] pg/ml and combination of mitral valve prolapse and type 1 diabetes [23.71 ±0.25] pg/ml (p<0.01). The level of peptide-bound oxyproline, just as the level of free oxyproline, significantly increased in patients with comorbid pathology, compared to the control group: [16.06 ±1.54] µmol/l versus [8.7 ±0.81] µmol/l (p<0.01) respectively. Conclusions. The most significant differences in the indices of intracardiac hemodynamics, fibroblast growth factor-2 and free and peptide-bounding oxyproline compared with control were observed in patients with combination of mitral valve prolapse and type 1 diabetes, which may indicate the influence of diabetic metabolic processes on further structural changes in the mitral valve.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2020 © The Author(s)
• Date:
  2020.12.17
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 10 No. 12 (2020); 304-313;
  Journal of Education, Health and Sport; Tom 10 Nr 12 (2020); 304-313;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.12.030/28435
• Subject:
  mitral valve prolapse;
  diabetes mellitus;
  fibroblast growth factor-2;
  free and peptide-bound oxyproline;
  cardiac valve degeneration;
  echocardiographic parameters of left ventricular hemodynemic.
• Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.12.030
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text