Object's details: Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis.

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis.
Creator:
Desjardins, Christopher A;
Champion, Mia D;
Holder, Jason W;
Muszewska, Anna;
Goldberg, Jonathan;
Bailão, Alexandre M;
Brigido, Marcelo Macedo;
Ferreira, Márcia Eliana da Silva;
Garcia, Ana Maria;
Grynberg, Marcin;
Gujja, Sharvari;
Heiman, David I;
Henn, Matthew R;
Kodira, Chinnappa D;
León-Narváez, Henry;
Longo, Larissa V G;
Ma, Li-Jun;
Malavazi, Iran;
Matsuo, Alisson L;
Morais, Flavia V;
Pereira, Maristela;
Rodríguez-Brito, Sabrina;
Sakthikumar, Sharadha;
Salem-Izacc, Silvia M;
Sykes, Sean M;
Teixeira, M.M.;
Vallejo, Milene C;
Walter, Maria Emília Machado Telles;
Yandava, Chandri;
Young, Sarah;
Zeng, Qiandong;
Zucker, Jeremy;
Felipe, Maria Sueli;
Goldman, Gustavo H;
Haas, Brian J;
McEwen, Juan G;
Nino-Vega, Gustavo;
Puccia, Rosana;
San-Blas, Gioconda;
Soares, Celia Maria de Almeida;
Birren, Bruce W;
Cuomo, Christina A
Description:
Paracoccidioides is a fungal pathogen and the cause of paracoccidioidomycosis, a health-threatening human systemic mycosis endemic to Latin America. Infection by Paracoccidioides, a dimorphic fungus in the order Onygenales, is coupled with a thermally regulated transition from a soil-dwelling filamentous form to a yeast-like pathogenic form. To better understand the genetic basis of growth and pathogenicity in Paracoccidioides, we sequenced the genomes of two strains of Paracoccidioides brasiliensis (Pb03 and Pb18) and one strain of Paracoccidioides lutzii (Pb01). These genomes range in size from 29.1 Mb to 32.9 Mb and encode 7,610 to 8,130 genes. To enable genetic studies, we mapped 94% of the P. brasiliensis Pb18 assembly onto five chromosomes. We characterized gene family content across Onygenales and related fungi, and within Paracoccidioides we found expansions of the fungal-specific kinase family FunK1. Additionally, the Onygenales have lost many genes involved in carbohydrate metabolism and fewer genes involved in protein metabolism, resulting in a higher ratio of proteases to carbohydrate active enzymes in the Onygenales than their relatives. To determine if gene content correlated with growth on different substrates, we screened the non-pathogenic onygenale Uncinocarpus reesii, which has orthologs for 91% of Paracoccidioides metabolic genes, for growth on 190 carbon sources. U. reesii showed growth on a limited range of carbohydrates, primarily basic plant sugars and cell wall components; this suggests that Onygenales, including dimorphic fungi, can degrade cellulosic plant material in the soil. In addition, U. reesii grew on gelatin and a wide range of dipeptides and amino acids, indicating a preference for proteinaceous growth substrates over carbohydrates, which may enable these fungi to also degrade animal biomass. These capabilities for degrading plant and animal substrates suggest a duality in lifestyle that could enable pathogenic species of Onygenales to transfer from soil to animal hosts.
Object availability:
free access
Rights:
cc_by
Date:
2011
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Relation: http://eprints.ibb.waw.pl/192
Subject:
QH301 Biology
Identifier: http://eprints.ibb.waw.pl/192/1/Paracoccidioides_PLoS_Genetics2011-journal.pgen.1002345.pdf ;
Desjardins, Christopher A and Champion, Mia D and Holder, Jason W and Muszewska, Anna and Goldberg, Jonathan and Bailão, Alexandre M and Brigido, Marcelo Macedo and Ferreira, Márcia Eliana da Silva and Garcia, Ana Maria and Grynberg, Marcin and Gujja, Sharvari and Heiman, David I and Henn, Matthew R and Kodira, Chinnappa D and León-Narváez, Henry and Longo, Larissa V G and Ma, Li-Jun and Malavazi, Iran and Matsuo, Alisson L and Morais, Flavia V and Pereira, Maristela and Rodríguez-Brito, Sabrina and Sakthikumar, Sharadha and Salem-Izacc, Silvia M and Sykes, Sean M and Teixeira, M.M. and Vallejo, Milene C and Walter, Maria Emília Machado Telles and Yandava, Chandri and Young, Sarah and Zeng, Qiandong and Zucker, Jeremy and Felipe, Maria Sueli and Goldman, Gustavo H and Haas, Brian J and McEwen, Juan G and Nino-Vega, Gustavo and Puccia, Rosana and San-Blas, Gioconda and Soares, Celia Maria de Almeida and Birren, Bruce W and Cuomo, Christina A (2011) Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis. PLoS genetics, 7 (10). e1002345. ISSN 1553-7404
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis.

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