Object's details: Low-complexity regions in fungi display functional groups and are depleted in positively charged amino acids

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Low-complexity regions in fungi display functional groups and are depleted in positively charged amino acids
Creator:
Steczkiewicz, Kamil;
Kossakowski, Aleksander;
Janik, Stanisław;
Muszewska, Anna
Description:
Reports on the diversity and occurrence of low-complexity regions (LCR) in Eukaryota are limited. Some studies have provided a more extensive characterization of LCR proteins in prokaryotes. There is a growing body of knowledge about a plethora of biological functions attributable to LCRs. However, it is hard to determine to what extent observed phenomena apply to fungi since most studies of fungal LCRs were limited to model yeasts. To fill this gap, we performed a survey of LCRs in proteins across all fungal tree of life branches. We show that the abundance of LCRs and the abundance of proteins with LCRs are positively correlated with proteome size. We observed that most LCRs are present in proteins with protein domains but do not overlap with the domain regions. LCRs are associated with many duplicated protein domains. The quantity of particular amino acids in LCRs deviates from the background frequency with a clear over-representation of amino acids with functional groups and a negative charge. Moreover, we discovered that each lineage of fungi favors distinct LCRs expansions. Early diverging fungal lineages differ in LCR abundance and composition pointing at a different evolutionary trajectory of each fungal group.
Object availability:
free access
Date:
2025.02.27
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Publisher:
Oxford
Relation: http://eprints.ibb.waw.pl/2526 ;https://academic.oup.com/nargab/article/7/1/lqaf014/
Subject:
QH301 Biology
Identifier: http://eprints.ibb.waw.pl/2526/1/LCR_2025.pdf ;
Steczkiewicz, Kamil and Kossakowski, Aleksander and Janik, Stanisław and Muszewska, Anna (2025) Low-complexity regions in fungi display functional groups and are depleted in positively charged amino acids. NAR Genomics and Bioinformatics .
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Low-complexity regions in fungi display functional groups and are depleted in positively charged amino acids

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