Object's details: Pathophysiological association of expression hormone of adipose tissue omentin-1 and the degree of vascular remodeling of brachyocephalic vessels in persons with obesity and disorders of carbohydrate metabolism

Provider:Akademicka Platforma Czasopism

Description

Title:
Pathophysiological association of expression hormone of adipose tissue omentin-1 and the degree of vascular remodeling of brachyocephalic vessels in persons with obesity and disorders of carbohydrate metabolism
Creator:
Kulynych, Roman Leonidovich;
Soloviuk, Olena Anatolyevna;
Soloviuk, Oleksandr Olegovich
Description:
Introduction. The relationship of visceral obesity and excess body weight (EBW) with the development of cardiovascular diseases, type 2 diabetes mellitus (DM) and effect on quality and duration of life determine the relevance of studying this problem.Objective: to assess omentin-1 metabolism and pathophysiological relationship between its level and the severity of lesions in the intima-media thickness (IMT) of the carotid arteries in type 2 DM in combination with EBW and obesity.Material and research methods. We examined 98 people with DM, the first group consisted of 64 people with EBW and obesity, second group consisted of 34 people with normal body weight, control group – 28 healthy individuals.Research results. Evaluation of the correlation matrix showed the presence of a positive rather strong negative connection between IMT, especially the right carotid artery and the level of omentin-1 in the blood (Rs = –0.55; p = 0.002). According to the results of the regression analysis and the study of the scatter diagram of the obtained data, the functional relationship between IMTright / IMTleft and the serum omentin-1 indicator was reliably approximated by a step-type model (polynomial curve, R = 0.49, R2 = 0.24, normalized R2 = 0.22 at F = 10.59, standard error 0.15, p <0.01)). The columnar bivariate 3D histogram clearly shows the physiological relationship between these indicators and indicates that the largest number of individuals with omentin-1 levels from 5-10 ng / ml had significant disorders of the vascular wall (IMT from 1.0 to 1.2 mm).Conclusion. Obtained data indicate a statistically significant associative relationship between the dynamics of the predictor of cardiovascular risk – IMT with the degree of impaired expression of omentin-1.
Object availability:
free access
Rights:
Prawa autorskie (c) 2020 © The Author(s)
Date:
2020.10.30
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 10 No. 10 (2020); 127-143;
Journal of Education, Health and Sport; Tom 10 Nr 10 (2020); 127-143;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.10.012/26969
Subject:
omentin-1;
obesity;
type 2 diabetes mellitus;
intima-media thickness;
cardiovascular risk.
Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.10.012
Data provider:
Akademicka Platforma Czasopism

Similar objects

Pathophysiological association of expression hormone of adipose tissue omentin-1 and the degree of vascular remodeling of brachyocephalic vessels in persons with obesity and disorders of carbohydrate metabolism

Creator:Kulynych, Roman Leonidovich | Soloviuk, Olena Anatolyevna | Soloviuk, Oleksandr Olegovich

Date:2020.10.30

Type:text

Sleep duration and cardiovascular outcomes

Date:2023.05.16

Type:text

Challenges in managing de novo diabetes in adults: A case report of a 47 year old male

Date:2025.05.05

Type:text

The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications: The importance of stem cells in diabetology

Date:2025.01.14

Type:text

The role of the IRS1 gene (rs2943640) in the comorbid course of type 2 diabetes mellitus, obesity and arterial hypertension

Creator:Vivsiana, I. | Habor, H. | Marushchak, M.

Date:2021.01.29

Type:text

Is Curcumin an Antidote for Civilization Diseases? A Literature Review

Date:2024.12.18

Type:text

Ultrasound therapy of diabetes mellitus type 2

Creator:Samosiuk, I. | Zubkova, S. | Chuhraeva, E. | Samosiuk, N. | Zukow, W.

Date:2011.02.20

Type:text

The influence of the ketogenic diet on the therapy of type 2 diabetes. A literature review

Date:2024.02.04

Type:text

Federacja Bibliotek Cyfrowych

Object's details: Pathophysiological association of expression hormone of adipose tissue omentin-1 and the degree of vascular remodeling of brachyocephalic vessels in persons with obesity and disorders of carbohydrate metabolism

Description

Similar objects