Description

• Title:
  Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation
• Creator:
  Kaźmierczak, Martyna;
  Parys, Jakub;
  Mikosińska, Agnieszka;
  Kałuziak, Patrycja;
  Jajczak, Marta;
  Mossakowski, Maciej;
  Witek, Aleksandra;
  Litwin, Mateusz;
  Jesionek, Stanisław
• Description:
  Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects women of reproductive age, characterized by hormonal imbalances, insulin resistance, and a range of clinical manifestations, including infertility and metabolic disturbances. Effective management of PCOS remains a challenge due to its multifaceted nature, necessitating a comprehensive understanding of therapeutic options. Aim of the Study: This paper aims to explore the role of various treatment modalities for PCOS, with a particular emphasis on the use of metformin, an antidiabetic medication increasingly recognized for its benefits in managing insulin resistance and other associated conditions in PCOS patients. Conclusion: The findings highlight metformin's three primary mechanisms of action: enhancing insulin sensitivity, inhibiting hepatic gluconeogenesis, and influencing lipid metabolism. Metformin is effective in improving metabolic parameters and restoring ovulatory function in women with PCOS. While it is a cornerstone of therapy, the management of PCOS requires a tailored approach that considers individual clinical symptoms and phenotypes. Additional therapeutic strategies, including non-pharmacological measures and other pharmacological agents, play a vital role in a comprehensive treatment plan for PCOS.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2025 Martyna Kaźmierczak, Jakub Parys, Agnieszka Mikosińska, Patrycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Stanisław Jesionek;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2025.01.07
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 77 (2025); 57421;
  Journal of Education, Health and Sport; Tom 77 (2025); 57421;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/57421/41058
• Subject:
  Polycystic Ovary Syndrome (PCOS);
  insulin resistance;
  hyperandrogenism;
  Rotterdam criteria;
  metformin;
  lifestyle interventions
• Identifier: https://apcz.umk.pl/JEHS/article/view/57421
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text