Description

• Title:
  Improving Reproductive Outcomes in PCOS: The Emerging Role of GLP-1 Receptor Agonists
• Creator:
  Tabeau, Adrianna;
  Pawlik, Agnieszka;
  Dudek, Patryk;
  Łuczak, Klaudia;
  Ulicka, Wiktoria;
  Pięta, Justyna;
  Sitarek, Hanna;
  Prus, Joanna;
  Chudzikowski, Marcel;
  Prokopiuk, Agata
• Description:
  Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting a significant proportion of women of reproductive age. It is associated with infertility, metabolic abnormalities, and hormonal imbalances, including insulin resistance and hyperandrogenism. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as exenatide and liraglutide, have shown promise in improving reproductive outcomes in women with PCOS. This review evaluates the potential benefits of GLP-1 RAs in enhancing fertility, with a focus on menstrual regularity, ovulation rates, pregnancy rates, and metabolic outcomes. Studies have indicated that GLP-1 RAs improve insulin sensitivity, reduce BMI, waist circumference, and testosterone levels, and contribute to higher natural pregnancy rates. Despite the promising results, the long-term safety of GLP-1 RAs, particularly during pregnancy, remains uncertain. Patients using GLP-1 RAs are advised to use contraception, as the safety profile during pregnancy is still under investigation. Further research is necessary to establish the long-term effects and safety of these medications in women with PCOS. Overall, GLP-1 RAs offer a potential therapeutic approach for improving fertility and metabolic health in women with PCOS.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Adrianna Tabeau, Agnieszka Pawlik, Patryk Dudek, Klaudia Łuczak, Wiktoria Ulicka, Justyna Pięta, Hanna Sitarek, Joanna Prus, Marcel Chudzikowski, Agata Prokopiuk
• Date:
  2025.03.25
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 79 (2025); 53347;
  Journal of Education, Health and Sport; Tom 79 (2025); 53347;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/59347/41968
• Subject:
  Polycystic ovary syndrome;
  PCOS;
  Glucagon-Like Peptide-1 Receptor Agonists;
  glp-1;
  pregnancy;
  gestation
• Identifier: https://apcz.umk.pl/JEHS/article/view/59347
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text