Object's details: Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems.

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems.
Creator:
Siwaszek, A;
Ukleja, M;
Dziembowski, Andrzej
Description:
The process of mRNA decay and surveillance is considered to be one of the main posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of stable, protein-coding transcripts is normally initiated by removal of the poly(A) tail followed by 5'-cap hydrolysis and degradation of the remaining mRNA body by Xrn1. Alternatively, the exosome complex degrades mRNA in the 3'>5'direction. The newly discovered uridinylation-dependent pathway, which is present in many different organisms, also seems to play a role in bulk mRNA degradation. Simultaneously, to avoid the synthesis of incorrect proteins, special cellular machinery is responsible for the removal of faulty transcripts via nonsense-mediated, no-go, non-stop or non-functional 18S rRNA decay. This review is focused on the major eukaryotic cytoplasmic mRNA degradation pathways showing many similarities and pointing out main differences between the main model-species: yeast, Drosophila, plants and mammals.
Object availability:
free access
Date:
2014.10.31
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Publisher:
Landes Bioscience
Relation: http://eprints.ibb.waw.pl/872 ;http://www.tandfonline.com/doi/abs/10.4161/rna.34406?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.VKJcW14AoI ;
25483043
Subject:
QH301 Biology
Identifier: http://eprints.ibb.waw.pl/872/1/KRNB_A_977153.pdf ;
Siwaszek, A and Ukleja, M and Dziembowski, Andrzej (2014) Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems. RNA Biology . ISSN 1099-0123 (In Press)
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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Object's details: Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems.

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