Object's details: Toxic cardiac effect of cobalt chloride excessive chronic consumption in male Wistar rats

Provider:Akademicka Platforma Czasopism

Description

Title:
Toxic cardiac effect of cobalt chloride excessive chronic consumption in male Wistar rats
Creator:
Sataieva, Tatiana P.;
Zadnipryany, Igor V.;
Zukow, Walery
Description:
Cobalt is widespread in the natural environment and can be formed as an effect of anthropogenic activity. The ionic cobalt can be transported by blood in the body, causing adverse effects by the generation of reactive oxygen species. The aim of this research was to describe the changes of myocardial cells during experimental cobalt induced cardiomyopathy. Summarizing the in vivo experiments, it can be stated that severe histotoxic cardiomyopathy occurred in male rats treated with cobalt chloride. Long-term oral administration of cobalt resulted in diminished dietary intake and growth inhibition in the exposed rats compared to the control group. The primary morphological alteration of cardiomyocytes is mitochondrial damage that possibly reflects an enzymatic block of oxidative decarboxylation. Due to that myofibrils of the myocardial cells were affected highlighting that the main cause of myofibril reduction could be a lower oxygen intake in the perinuclear area. The reduction of the contractile support of myocardial cells can explain the possible myocardial dysfunction. Knowing structural changes in cardiomyocytes could explain the pathophysiology of the disease and allow a correct therapeutic approach.
Object availability:
free access
Rights:
Prawa autorskie (c) 2019 Ecological Questions
Date:
2019.05.21
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Ecological Questions; Vol. 30 No. 3 (2019); 25-32;
Ecological Questions; Tom 30 Nr 3 (2019); 25-32;
1644-7298
Format:
application/pdf
Publisher:
Uniwersytet Mikołaja Kopernika w Toruniu
Relation: https://apcz.umk.pl/EQ/article/view/EQ.2019.016/17600
Subject:
cobalt chloride;
myocardium;
cardiomyocyte;
mitochondria;
histotoxic hypoxia;
rats
Identifier: https://apcz.umk.pl/EQ/article/view/EQ.2019.016
Data provider:
Akademicka Platforma Czasopism

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Object's details: Toxic cardiac effect of cobalt chloride excessive chronic consumption in male Wistar rats

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