Description

• Tytuł:
  The Neuroprotective Effects of GLP-1 Analogues on Alzheimer's Disease – A Literature Review
• Twórca:
  Ulicka, Wiktoria;
  Dudek, Patryk;
  Łuczak, Klaudia;
  Marcel Chudzikowski;
  Pawlik, Agnieszka;
  Pięta, Justyna;
  Tabeau, Adrianna;
  Sitarek, Hanna;
  Prus, Joanna;
  Prokopiuk, Agata
• Opis:
  Alzheimer’s disease (AD), often referred to as type 3 diabetes, is characterized by neuroinflammation, oxidative stress, mitochondrial dysfunction, and brain insulin resistance, leading to cognitive decline. GLP-1 receptor agonists, originally developed for type 2 diabetes, demonstrate neuroprotective properties that address these pathologies. They improve insulin sensitivity, reduce amyloid-beta deposition, tau hyperphosphorylation, and neuronal apoptosis while enhancing synaptic plasticity, autophagy, and neural stem cell proliferation. Studies highlight their potential as innovative AD therapies. However, further research is needed to confirm their efficacy and long-term safety in combating neurodegeneration.
• Dostępność obiektu:
  free access
• Prawa:
  Prawa autorskie (c) 2025 Wiktoria Ulicka, Patryk Dudek, Klaudia Łuczak, Marcel Chudzikowski, Agnieszka Pawlik, Justyna Pięta, Adrianna Tabeau, Hanna Sitarek, Joanna Prus, Agata Prokopiuk;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Data:
  2025.04.22
• Typ:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Język:
  English
• Źródło:
  Journal of Education, Health and Sport; Vol. 80 (2025); 59398;
  Journal of Education, Health and Sport; Tom 80 (2025); 59398;
  2391-8306
• Format:
  application/pdf
• Wydawca:
  Nicolaus Copernicus University, Toruń, Poland
• Relacja: https://apcz.umk.pl/JEHS/article/view/59398/42273
• Temat i słowa kluczowe:
  Alzheimer's disease;
  GLP-1;
  glucagon like peptide 1;
  neuroprotection
• Identyfikator: https://apcz.umk.pl/JEHS/article/view/59398
• Dostawca danych:
  Akademicka Platforma Czasopism
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