Description

• Title:
  Etiology, Epidemiology, and Therapeutic Approaches for Primary Sclerosing Cholangitis in the Context of Concurrent Non-specific Inflammatory Bowel Diseases
• Creator:
  Olszewska, Anna;
  Matyja, Karolina;
  Berner, Aleksandra;
  Stencel, Katarzyna;
  Stelmaszak, Karina;
  Marczyk, Klaudia;
  Polak, Paulina;
  Pękała, Maciej;
  Polaszek, Monika;
  Bogowska, Marta
• Description:
  Introduction: Primary sclerosing cholangitis (PSC) is a chronic, idiopathic disease characterized by persistent and progressive inflammation of the intrahepatic and/or extrahepatic bile ducts. This leads to fibrosis, cholestatic complications, and liver failure. In over 70% of patients, non-specific intestinal inflammations coexist, particularly ulcerative colitis, and sporadically Crohn's disease. Aim: Our study aimed to assess current literature on primary sclerosing cholangitis (PSC), covering its causes, symptoms, treatment methods, and the connection between PSC and inflammatory bowel disease (IBD) co-occurrence. Materials and methods: We conducted a PubMed literature review using keywords like "primary sclerosing cholangitis pathogenesis," "primary sclerosing cholangitis and inflammatory bowel disease," and "primary sclerosing cholangitis and ulcerative colitis.” Results: Our research extensively covered PSC epidemiology, pathogenesis, and treatment options. Emphasis was placed on the heightened prevalence of inflammatory bowel diseases, including ulcerative colitis, among PSC patients. Summary: Primary sclerosing cholangitis (PSC) is a disease causing gradual damage to bile ducts within or outside the liver. Over 70% of patients also experience inflammatory bowel disease (IBD), mainly ulcerative colitis. The exact causes of PSC and its connection to IBD remain unclear. The theories involve hyperactive "intestinal" T cells or the impact of gut microbiome on their growth. Presently, a liver transplant stands as the sole remedy.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2024 Anna Olszewska, Karolina Matyja, Aleksandra Berner, Katarzyna Stencel, Karina Stelmaszak, Klaudia Marczyk, Paulina Polak, Maciej Pękała, Monika Polaszek, Marta Bogowska
• Date:
  2024.02.14
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 60 (2024); 44-57;
  Journal of Education, Health and Sport; Tom 60 (2024); 44-57;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/48172/37649
• Subject:
  p;
  psc;
  psc and ibd;
  primary sclerosing cholangitis;
  primary sclerosing cholangitis and inflammatory bowel disease
• Identifier: https://apcz.umk.pl/JEHS/article/view/48172
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text