Description

• Title:
  Advancements in Alzheimer's Disease Therapy: The Role of Anti-Amyloid Monoclonal Antibodies - A Literature Review
• Creator:
  Skoczeń, Agnieszka;
  Rutecka, Natalia;
  Kaczmarek, Błażej;
  Kuśnierz-Gibała, Agata;
  Kruk, Adrian;
  Kulesza, Michał;
  Wawrzynów, Weronika;
  Miłoś, Martyna;
  Dorosz, Aleksandra;
  Jakubowska, Magdalena Maria
• Description:
  Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive decline and neuronal damage. Anti-amyloid monoclonal antibodies such as aducanumab, lecanemab, and donanemab, represent the first disease-modifying therapies for Alzheimer’s disease, specifically targeting amyloid-β plaques, a hallmark of the disease. This review examines the pathogenesis of Alzheimer’s disease, the mechanism of action of these anti-amyloid therapies, and their potential benefits and associated risks, particularly amyloid-related imaging abnormalities (ARIA). While these therapies have demonstrated statistically significant efficacy in reducing amyloid plaques and decelerating cognitive decline, further research is required to confirm their long-term clinical benefits and establish a precise safety profile. Nonetheless, the approval of these monoclonal antibodies constitutes a significant advancement and potentially heralds the beginning of a new era in the treatment of Alzheimer’s disease.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Agnieszka Skoczeń, Natalia Rutecka, Błażej Kaczmarek, Agata Kuśnierz-Gibała, Adrian Kruk, Michał Kulesza, Weronika Wawrzynów, Martyna Miłoś, Aleksandra Dorosz, Magdalena Maria Jakubowska
• Date:
  2025.03.06
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 79 (2025); 58362;
  Journal of Education, Health and Sport; Tom 79 (2025); 58362;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/58362/41740
• Subject:
  Alzheimer's disease;
  anti-amyloid monoclonal antibodies;
  aducanumab;
  lecanemab;
  donanemab;
  ARIA
• Identifier: https://apcz.umk.pl/JEHS/article/view/58362
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text