Description

• Title:
  The influence of Helicobacter pylori on the level of endotheline-1 and nitrogen oxide in the blood of children with the duodenal ulcer
• Creator:
  Sorokman, Tаmila;
  Chernei, Nadiia;
  Sokolnyk, Snizhana;
  Sokolnyk, Iryna;
  Popelyuk, Nataliya
• Description:
  The most serious pathology of the of gastrointestinal tract in children remains duodenal ulcer (DU). Interesting is the study of the role of endothelin-1 and nitrogen oxide in the formation of DU.The aim. To evaluate the nature of changes in the level of nitrogen oxide (NO) and endothelin-1 (Et-1) in the blood of children with H pylori-associated DU.Methods. A single-center study was conducted in 42 children with DU aged 6–18 years and 20 children comparison group. Diagnostics of H. pylori was performed primary endoscopy and 4 weeks after the end of treatment. Blood samples were collected in each visit to measure plasma Et-1 using an enzyme immunoassay kit and NO (nitrate/nitrite) levels Golikov's method.Results. In 37 (92.5%) the ulcers went through re-epithelialization, while successful eradication of H. pylori was achieved in 32 people (80%). The NO level in the blood plasma of the children of the main group was 9.78 ± 1.13 mmol/l, after treatment –11.09 ± 1.2 mmol/l. After eradication of H. pylori, the level of Et-1 decreased from 2.39 ± 0.08 to 1.14 ± 0.07 pg / ml.Conclusion. Levels of endothelin-1 (Et-1) and nitrogen oxide (NO) in children with duodenal ulcer vary depending on the stage of the disease. After H-pylori eradication, ulcer defect healing is associated with decreased of Et-1 inplasma and increased NO activity.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2020 © The Author(s)
• Date:
  2020.11.30
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 10 No. 11 (2020); 261-272;
  Journal of Education, Health and Sport; Tom 10 Nr 11 (2020); 261-272;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.11.026/27901
• Subject:
  Children;
  H. pylori;
  Duodenal ulcer;
  Endothelin-1;
  Nitrogen oxide
• Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.11.026
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text