Object's details: Repurposing Metformin: Potential as a Prevention, Treatment and Adjunct Therapy in Pancreatic Cancer

Provider:Akademicka Platforma Czasopism

Description

Title:
Repurposing Metformin: Potential as a Prevention, Treatment and Adjunct Therapy in Pancreatic Cancer
Creator:
Kamizela, Emilia;
Rudzińska, Anna;
Ponikowski, Kacper;
Wrzosek, Kacper;
Gumółka, Paulina;
Oberda, Jakub;
Paluch, Alicja;
Haba, Sylwia;
Jakubik, Karol;
Kolasa, Eliza;
Szklener, Katarzyna
Description:
Metformin, a widely prescribed treatment for type II diabetes, offers promising benefits beyond glycemic control, including improved lipid profiles and cardiovascular outcomes. It inhibits gluconeogenesis in the liver by activating AMPK, thereby reducing glucose production and enhancing glucose uptake in muscle. Recent studies highlight its potential anticancer effects, particularly through the suppression of the mTOR pathway via LKB1-dependent AMPK activation, which inhibits cell proliferation. This review explores metformin’s role as an adjunct therapy in pancreatic cancer, summarizing evidence on its molecular mechanisms and potential efficacy. The findings suggest metformin’s broader therapeutic applications, especially in oncology, warrant further investigation. The aim: The aim of this study is to analyze the role of metformin as an adjunct therapy in the treatment of pancreatic cancer, with particular focus on its molecular mechanisms, such as AMPK activation and mTOR pathway inhibition. The study aims to summarize the current scientific evidence regarding its potential effectiveness.
Object availability:
free access
Rights:
Prawa autorskie (c) 2024 Emilia Kamizela, Anna Rudzińska, Kacper Ponikowski, Kacper Wrzosek, Paulina Gumółka, Jakub Oberda, Alicja Paluch, Sylwia Haba, Karol Jakubik, Eliza Kolasa, Katarzyna Szklener;
https://creativecommons.org/licenses/by-nc-sa/4.0
Date:
2024.12.20
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Quality in Sport; Tom 36 (2024); 56451;
Quality in Sport; Vol. 36 (2024); 56451;
2450-3118
Format:
application/pdf
Publisher:
University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
Relation: https://apcz.umk.pl/QS/article/view/56451/40816
Subject:
metformin;
glycemic control;
pancreatic cancer;
oncology
Identifier: https://apcz.umk.pl/QS/article/view/56451
Data provider:
Akademicka Platforma Czasopism

Similar objects

Repurposing Metformin: Potential as a Prevention, Treatment and Adjunct Therapy in Pancreatic Cancer

Date:2024.12.20

Type:text

Intelligent Detection for Pancreatic Cancer Diagnosis: Future Directions

Date:2023.09.05

Type:text

New-onset diabetes mellitus type 2 treated with metformin - is it possible to slow the development of pancreatic cancer?- case report: New-onset DM2 and pancreatic cancer treated with metformin

Date:2024.09.18

Type:text

Advancements in Pancreatic Cancer Treatment: A Comprehensive Review of Current Therapies and Future Directions

Date:2024.10.22

Type:text

Microbial alterations of oral cavity and their association with Pancreatic Cancer

Date:2023.01.31

Type:text

PARP inhibitors in the treatment of Pancreatic Cancer - A Review of literature

Date:2025.01.22

Type:text

Diagnosis of the pancreatic cancer

Creator:Raczkiewicz, Przemysław | Kalicka, Maria | Korzec, Tomasz | Kania, Konrad | Cyboran, Katarzyna

Date:2021.09.05

Type:text

Videothoracoscopic splanchnicectomy as a method of treatment of the chronic pain syndromes in pancreatic cancer and chronic pancreatitis

Date:2023.04.03

Type:text

Federacja Bibliotek Cyfrowych

Object's details: Repurposing Metformin: Potential as a Prevention, Treatment and Adjunct Therapy in Pancreatic Cancer

Description

Similar objects