Object's details: Expression of the VEGF marker in endometrial cells in hyperplastic processes

Provider:Akademicka Platforma Czasopism

Description

Title:
Expression of the VEGF marker in endometrial cells in hyperplastic processes
Creator:
Chumak, Z. V.
Description:
Hormone-dependent diseases related to preproliferative processes and endometrial cancer have a clear tendency to increase and rejuvenate. The purpose: to study the expression of VEGF marker in endometrial cells under physiological, hyperplastic, atypical conditions in women’s different age periods. 2196 pathomorphological findings of endometrial tissue samples in women with clinical manifestations requiring surgical treatment have been analyzed. VEGF expression was performed in endometrial tissue samples of 458 women of late reproductive, perimenopausal and postmenopausal age. Each age category is characterized by its morphofunctional features of the endometrial tissue. Results. The frequency of detection of hyperplastic processes, atypical hyperplasia and adenocarcinoma indicates that starting from the period after 40 y.o. the mechanisms of initiation and development of factors in the system of self-sufficiency in mitogenic stimuli, constant proliferation and insensitivity to antimytogenic signals", loss of “Hayflick’s limit”, reduced ability to apoptosis, propensity to immortalization take place. Conclusion: The expression of VEGF concentration in endometrial tissue as an inducer of angiogenesis is increased in hyperplastic processes. Significant growth is observed in the processes of atypical hyperplasia, especially in the postmenopausal period. Determination of VEGF concentration in endometrial proliferative processes can be a promising marker for diagnosing the risk of atypical conditions and their prognosis. Research in this direction is quite relevant.
Object availability:
free access
Rights:
Prawa autorskie (c) 2020 © The Author (s)
Date:
2020.10.20
Type:
info:eu-repo/semantics/article;
info:eu-repo/semantics/publishedVersion
Language:
English
Source:
Journal of Education, Health and Sport; Vol. 10 No. 10 (2020); 82-89;
Journal of Education, Health and Sport; Tom 10 Nr 10 (2020); 82-89;
2391-8306
Format:
application/pdf
Publisher:
Nicolaus Copernicus University, Toruń, Poland
Relation: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.10.008/26827
Subject:
endometrial hyperplasia;
atypical endometrial hyperplasia;
angiogenesis;
VEGF;
malignancy
Identifier: https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.10.008
Data provider:
Akademicka Platforma Czasopism

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