Description

• Title:
  Physical Exercise as a Therapeutic Strategy in Alzheimer’s Disease: Mechanisms and Benefits
• Creator:
  Bartoszek, Aleksandra;
  Kopeć, Karolina;
  Adamiuk, Julia;
  Marut, Agnieszka;
  Biskup, Marta;
  Misiuk, Jagoda;
  Skuba, Adriana;
  Załuska, Katarzyna;
  Świdniak, Agnieszka;
  Nykiel, Sylwia
• Description:
  Introduction and Purpose  Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no definitive cure. This article explores the impact of physical exercise on AD risk reduction and disease progression, emphasizing its molecular, cognitive, and physiological benefits. Materials and Methods  A comprehensive review of recent studies, meta-analyses, and clinical trials was conducted to evaluate the effects of various exercise modalities on AD-related pathophysiology, cognitive decline, and neuroprotection. Results  Findings indicate that regular physical activity is associated with a 33% lower risk of developing AD. Exercise interventions lasting over 16 weeks significantly improve cognitive function, as measured by MMSE and ADL scores. Mechanistically, exercise enhances BDNF levels, promotes Aβ clearance, reduces tau pathology, mitigates neuroinflammation, and improves cerebrovascular health. Conclusion Physical exercise is a cost-effective, non-invasive intervention for AD prevention and management. Future research should focus on optimizing individualized exercise protocols and leveraging digital health technologies for long-term adherence and effectiveness.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Aleksandra Bartoszek, Karolina Kopeć, Julia Adamiuk, Agnieszka Marut, Marta Biskup, Jagoda Misiuk, Adriana Skuba, Katarzyna Załuska, Agnieszka Świdniak, Sylwia Nykiel
• Date:
  2025.05.14
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Quality in Sport; Tom 41 (2025); 58848;
  Quality in Sport; Vol. 41 (2025); 58848;
  2450-3118
• Format:
  application/pdf
• Publisher:
  University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
• Relation: https://apcz.umk.pl/QS/article/view/58848/42566
• Subject:
  Alzheimer's disease;
  physical exercise;
  neuroprotecion;
  cognitive decline;
  BDNF;
  Neuroinflammation
• Identifier: https://apcz.umk.pl/QS/article/view/58848
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text