Description

• Title:
  Wilms Tumor - Pathogenesis, diagnosis, treatment and prognosis
• Creator:
  Milczek, Maria;
  Warzyszak, Paweł;
  Żołyniak, Wojciech;
  Tomasik, Mikołaj;
  Hawranik, Izabela;
  Żaba, Ziemowit;
  Niski, Szymon;
  Małek, Róża;
  Lisowska, Aleksandra;
  Skrzypek, Mateusz
• Description:
  Introduction: Wilms tumor is the most common occuring malignant tumor of kidney among children. Mostly appears in infants and young children. The main symptom is enlargement od the abdomen. It is often diagnosed incidentally during USG examination. Aim of the study: Summary of current knowledge on the pathogenesis, diagnosis, treatment and prognosis of Wilms Tumor. Methods and matherials: A review of  the literaturę available in the PubMed data base, using the following keywords: :„Wilms Tumor”,„Wilms tumor genetics” State of knowledge: Wilms tumor appears more often among people with certain genetic syndromes. There are two to treat WT depending on the world region (SIOP, COG). According to SIOP, the diagnosis is made based on imaging. This is followed by neoadiuvant chemotherapy, and then it is surgically removed. According to COG, the first stage of treatment is surgical removal of the tumor, then chemotherapy. During chemotherapy, vincristine, actinomycin, doxodubicin are used in both schemes. Although both strategies differ in their pretreatment approach, they lead to similar overall survival rates. Conclusions:Despite already advanced treatment techniques for the tumor, and extensive knowledge about it, its pathogenesis still remains somewhat unknown. Increased understanding of the aberrant molecular pathways active in Wilms tumorigenesis has identified many potential targeted therapeutic approaches that could be applied in a clinical setting
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2022 Maria Milczek, Paweł Warzyszak, Wojciech Żołyniak, Mikołaj Tomasik, Izabela Hawranik, Ziemowit Żaba, Szymon Niski, Róża Małek, Aleksandra Lisowska, Mateusz Skrzypek
• Date:
  2022.12.19
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Quality in Sport; Tom 8 Nr 4 (2022); 39-45;
  Quality in Sport; Vol. 8 No. 4 (2022); 39-45;
  2450-3118
• Format:
  application/pdf
• Publisher:
  University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
• Relation: https://apcz.umk.pl/QS/article/view/41434/34168
• Subject:
  wilms tumor;
  wilm's tumor
• Identifier: https://apcz.umk.pl/QS/article/view/41434
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text