Object's details: The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker

Provider:Repozytorium Uniwersytetu Łódzkiego

Description

Title:
The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker
Creator:
Grabarek, Beniamin;
Bednarczyk, Martyna;
Mazurek, Urszula
Contributor:
Grabarek, Beniamin - Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland;
Bednarczyk, Martyna - Department of Internal Medicine, Medical University of Silesia, School of Public Health in Bytom, Żeromskiego Street 7, 41-902 Bytom, Poland;
Mazurek, Urszula - Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland;
Grabarek, Beniamin - beniamin.grabarek@med.sum.edu.pl
Description:
The inflammatory process is directly associated with secretion of cytokines, e.g. tumor necrosis factor alpha (TNF-α). This molecule is one of the 22 proteins which belong to TNF family and is secreted mainly by: macrophages, monocytes, T lymphocyte and mast cells. The biological effects of TNF-α is possible through binding this cytokine to specific receptors - TNFR1 and TNFR2. The large number of reports provides that this cytokine plays extremely important role in cancers and cardiovascular disease - two groups of inflammatory diseases. Unfortunately, these diseases are the main cause of death in spite of advances in medicine and increasing public awareness of prevention. It is believed that better understanding both molecular potential of this cytokine and the impact in cancerogenesis and others inflammatory diseases may cause using TNF-α as a molecular marker in these diseases and will make it possible to observe the effects of anti-inflammatory therapy. It will be able to cause a drop in the incidence of these diseases and better monitoring of them.
Object availability:
free access
Rights:
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.;
http://creativecommons.org/licenses/by-nc-nd/4.0
Date:
2018.04.03;
2017.12.29
Format:
application/pdf
Publisher:
Wydawnictwo Uniwersytetu Łódzkiego
Relation:
Folia Biologica et Oecologica;13
Subject:
cytokine;
inflammatory process;
cancerogenesis;
cardiovascular diseases;
marker
Identifier:
1730-2366;
http://hdl.handle.net/11089/24313 ;
10.1515/fobio-2017-0001
Data provider:
Repozytorium Uniwersytetu Łódzkiego

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