Description

• Title:
  Akkermansia muciniphila – multifunctional bacteria
• Creator:
  Wosińska, Alicja;
  Pazik, Dorota;
  Łopuszyńska, Inga;
  Kosecka, Katarzyna;
  Rudziński, Patryk;
  Cieślik, Aleksandra;
  Jargieło, Anna;
  Kosieradzka, Karolina;
  Adamowicz, Dominik;
  Stańczyk, Justyna
• Description:
  Introduction: The complex symbiotic connection between the host and the gut microbiome, which has many important functions in the organism, provides an opportunity for dysbiosis to potentially serve as a catalyst for various health disorders. Akkermancia muciniphila, a bacterium that degadates mucin, is a noteworthy element of the human gut microbiome and has captured the attention of researchers due to its correlation with numerous diseases. Aim of the study: The purpose of this research was to review literature and determine the impact of Akkermansia muciniphila in selected diseases. A systematic review was conducted using PubMed database. State of knowledge: Studies have shown that reduced numbers of Akkermansia muciniphila have been associated with many diseases, including obesity, type 2 diabetes, atherosclerosis, fatty liver, some neurological conditions, inflammation, and response to cancer immunotherapies. Furthermore, the administration of this bacterium has been shown to have a positive impact on reducing obesity-related parameters, improving insulin sensitivity and glucose homeostasis, mitigating inflammation, and enhancing the prognosis of immune checkpoint inhibitor treatment.  Conclusions: The condition and composition of the intestinal microbiome play a significant role in the development and progression of numerous diseases. Akkermansia muciniphila, as demonstrated in various studies, is an example of a bacterium associated with beneficial effects in multiple diseases. It is regarded as a promising candidate for probiotic use.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2023 Alicja Wosińska, Dorota Pazik, Inga Łopuszyńska, Katarzyna Kosecka, Patryk Rudziński, Aleksandra Cieślik, Anna Jargieło, Karolina Kosieradzka, Dominik Adamowicz, Justyna Stańczyk;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2023.07.25
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 21 No. 1 (2023); 78-91;
  Journal of Education, Health and Sport; Tom 21 Nr 1 (2023); 78-91;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/44833/36170
• Subject:
  gut microbiota;
  Akkermansia muciniphila;
  probiotic;
  dysbiosis;
  metabolic diseases
• Identifier: https://apcz.umk.pl/JEHS/article/view/44833
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text