Description

• Title:
  PANDAS and PANS: Pathophysiology, Diagnostics and Therapeutic Approaches in Pediatric Autoimmune Neuropsychiatric Disorders – a literature review
• Creator:
  Galanty-Ochyra, Aleksandra;
  Jabłońska, Olga;
  Nosal, Aleksandra;
  Czarnecki, Adam;
  Zając, Piotr;
  Węgrzyn, Jan;
  Fijałkowski, Łukasz;
  Serwońska, Karolina;
  Pastuszka, Artur
• Description:
  Introduction and PurposePANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) and PANS (pediatric acute-onset neuropsychiatric syndrome) are neuropsychiatric disorders that have been debated since their first descriptions. PANDAS is linked to Group A Streptococcus (GAS) infections and is characterized by the sudden onset of symptoms such as OCD and tics after GAS infection. PANS involves a broader spectrum of symptoms without a specific GAS trigger. Both conditions are under-researched, and diagnosing and treating them is challenging. This article summarizes the current knowledge on PANDAS and PANS, focusing on their etiology, diagnosis, and treatment. Description of the State of KnowledgePANDAS and PANS are marked by the sudden onset of OCD or severe food intake restrictions, alongside other neuropsychiatric symptoms. Clinical criteria for PANDAS were proposed in 1998, linking it to GAS infections, and in 2012, broader PANS criteria were introduced, expanding the possible causes. The pathophysiology remains unclear, with theories suggesting autoimmune processes or neuroinflammation. Diagnosis is complicated by symptom overlap with other disorders. Treatment often involves a multidisciplinary approach, including behavioral therapy and, in some cases, antibiotics for GAS infections. The effectiveness of immunomodulatory therapies remains debated. ConclusionsPANDAS and PANS are complex disorders with sudden-onset symptoms, but diagnosing them is difficult due to unclear pathophysiology and overlapping symptoms. Further research is needed to better understand the underlying mechanisms and improve diagnostic and therapeutic approaches.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Aleksandra Galanty-Ochyra, Olga Jabłońska, Aleksandra Nosal, Adam Czarnecki, Piotr Zając, Jan Węgrzyn, Łukasz Fijałkowski, Karolina Serwońska, Artur Pastuszka
• Date:
  2025.03.03
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 79 (2025); 57830;
  Journal of Education, Health and Sport; Tom 79 (2025); 57830;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/57830/41664
• Subject:
  PANDAS;
  PANS;
  Obsessive-Compulsive Disorder;
  Group A Streptococcus;
  Neuroinflammatory Disease
• Identifier: https://apcz.umk.pl/JEHS/article/view/57830
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text