Description

• Title:
  Nitrazepam and 7-aminonitrazepam studied at the macroscopic and microscopic electrified liquid-liquid interface
• Creator:
  Stelmaszczyk, Paweł;
  Kwaczyński, Karolina;
  Rudnicki, Konrad;
  Skrzypek, Slawomira;
  Wietecha-Posłuszny, Renata;
  Półtorak, Łukasz
• Contributor:
  Laboratory for Forensic Chemistry, Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krakow, Poland;
  Electrochemistry@Soft Interfaces Team, Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland;
  lukasz.poltorak@chemia.uni.lodz.p;
  renata.wietecha-posluszny@uj.edu.pl
• Description:
  Two benzodiazepine type drugs, that is, nitrazepam and 7-aminonitrazepam, were studied at the electrified liquid-liquid interface (eLLI). Both drugs are illicit and act sedative in the human body and moreover are used as date rape drugs. Existence of the diazepine ring in the concerned chemicals structure and one additional amine group (for 7-aminonitrazepam) allows for the molecular charging below their pKa values, and hence, both drugs can cross the eLLI interface upon application of the appropriate value of the Galvani potential difference. Chosen molecules were studied at the macroscopic eLLI formed in the four electrode cell and microscopic eLLI formed within a microtip defined as the single pore having 25 μm in diameter. Microscopic eLLI was formed using only a few μL of the organic and the aqueous phase with the help of a 3D printed cell. Parameters such as limit of detection and voltammetric detection sensitivity are derived from the experimental data. Developed methodology was used to detect nitrazepam in pharmaceutical formulation and both drugs (nitrazepam and 7-aminonitrazepam) in spiked biological fluids (urine and blood).;
  R. Wietecha-Posłuszny and P. Stelmaszczyk are grateful for the financial support (National Science Centre, Grant no. UMO-2019/35/O/ST4/00978: application of developed extraction procedure, study the interfacial behavior of NIT and 7a-NIT), so is L. Poltorak (National Science Centre, Grant no. UMO-2018/31/D/ST4/03259: application of designed fused silica capillary and 3D printed cell for NIT and 7a-NIT detection).
• Object availability:
  free access
• Rights:
  Uznanie autorstwa 4.0 Międzynarodowe;
  http://creativecommons.org/licenses/by/4.0
• Date:
  2023.08.01;
  2023
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  Springer Nature
• Relation:
  Microchimica Acta;190:182
• Subject:
  Date rape drugs;
  Psychoactive chemicals;
  Voltammetry;
  ITIES;
  Electrochemical sensor
• Identifier:
  Stelmaszczyk, P., Kwaczyński, K., Rudnicki, K. et al. Nitrazepam and 7-aminonitrazepam studied at the macroscopic and microscopic electrified liquid-liquid interface. Microchim Acta 190, 182 (2023). https://doi.org/10.1007/s00604-023-05739-6;
  0026-3672;
  http://hdl.handle.net/11089/47741 ;
  1436-5073;
  10.1007/s00604-023-05739-6
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  check license
• Type:
  image