Description

• Title:
  The Multi-Biomarker Approach for Heart Failure in Patients with Hypertension
• Creator:
  Bielecka-Dabrowa, Agata;
  Gluba-Brzózka, Anna;
  Michalska-Kasiczak, Marta;
  Misztal, Małgorzata;
  Rysz, Jacek;
  Banach, Maciej
• Contributor:
  Bielecka-Dabrowa Agata, Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz;
  Gluba-Brzózka Anna, Department of Nephrology, Hypertension and Family Medicine, Chair of Nephrology and Hypertension, Medical University of Lodz;
  Michalska-Kasiczak Marta, Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz;
  Misztal Małgorzata, Chair of Statistical Methods, Faculty of Economics and Sociology, University of Lodz;
  Rysz Jacek, Department of Nephrology, Hypertension and Family Medicine, Chair of Nephrology and Hypertension, Medical University of Lodz;
  Banach Maciej, Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz;
  agatbiel7@poczta.onet.pl
• Description:
  We assessed the predictive ability of selected biomarkers using N-terminal pro-brain natriuretic peptide (NT-proBNP) as the benchmark and tried to establish a multi-biomarker approach to heart failure (HF) in hypertensive patients. In 120 hypertensive patients with or without overt heart failure, the incremental predictive value of the following biomarkers was investigated: Collagen III N-terminal propeptide (PIIINP), cystatin C (CysC), lipocalin-2/NGAL, syndecan-4, tumor necrosis factor-α (TNF-α), interleukin 1 receptor type I (IL1R1), galectin-3, cardiotrophin-1 (CT-1), transforming growth factor β (TGF-β) and N-terminal pro-brain natriuretic peptide (NT-proBNP). The highest discriminative value for HF was observed for NT-proBNP (area under the receiver operating characteristic curve (AUC) = 0.873) and TGF-β (AUC = 0.878). On the basis of ROC curve analysis we found that CT-1 > 152 pg/mL, TGF-β < 7.7 ng/mL, syndecan > 2.3 ng/mL, NT-proBNP > 332.5 pg/mL, CysC > 1 mg/L and NGAL > 39.9 ng/mL were significant predictors of overt HF. There was only a small improvement in predictive ability of the multi-biomarker panel including the four biomarkers with the best performance in the detection of HF—NT-proBNP, TGF-β, CT-1, CysC—compared to the panel with NT-proBNP, TGF-β and CT-1 only. Biomarkers with different pathophysiological backgrounds (NT-proBNP, TGF-β, CT-1, CysC) give additive prognostic value for incident HF in hypertensive patients compared to NT-proBNP alone.;
  The study was financed by JUVENTUS PLUS grant 2012 (No. IP2011003271) of the Polish Ministry of Science and Higher Education (MNiSW) and research grant of Medical University in Lodz and MNiSW No. 502-03/5-139-02/502-54-008.
• Object availability:
  free access
• Rights:
  Uznanie autorstwa 3.0 Polska;
  http://creativecommons.org/licenses/by/3.0/pl
• Date:
  2015.09.09;
  2015.05.12
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  MDPI AG
• Relation:
  International Journal of Molecular Sciences;2015;
  16
• Subject:
  hypertension;
  biomarkers;
  heart failure
• Identifier:
  1422-0067;
  http://hdl.handle.net/11089/11739 ;
  10.3390/ijms160510715
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  check license
• Type:
  image