Object's details: Halogen bonds involved in binding of halogenated ligands by protein kinases.

Provider:Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

Description

Title:
Halogen bonds involved in binding of halogenated ligands by protein kinases.
Creator:
Poznański, Jarosław;
Winiewska, Maria;
Czapinska, Honorata;
Poznańska, Anna;
Shugar, David
Description:
Analysis of 664 known structures of protein kinase complexes with halogenated ligands revealed 424 short contacts between a halogen atom and a potential protein X-bond acceptor, the topology and geometry of which were analyzed according to the type of a halogen atom (X = Cl, Br, I) and a putative protein X-bond acceptor. Among 236 identified halogen bonds, the most represented ones are directed to backbone carbonyls of the hinge region and may replace the pattern of ATP-like hydrogen bonds. Some halogen-π interactions with either aromatic residues or peptide bonds, that accompany the interaction with the hinge region, may possibly enhance ligand selectivity. Interestingly, many of these halogen-π interactions are bifurcated. Geometrical preferences identify iodine as the strongest X-bond donor, less so bromine, while virtually no such preferences were observed for chlorine; and a backbone carbonyl as the strongest X-bond acceptor. The presence of a halogen atom in a ligand additionally affects the properties of proximal hydrogen bonds, which according to geometrical parameters get strengthened, when a nitrogen of a halogenated ligand acts as the hydrogen bond donor.
Object availability:
free access
Date:
2016
Type:
Article;
PeerReviewed
Language:
English
Format:
application/pdf
Relation: http://eprints.ibb.waw.pl/1199
Subject:
Q Science (General)
Identifier: http://eprints.ibb.waw.pl/1199/1/JP-ABP-final.pdf ;
Poznański, Jarosław and Winiewska, Maria and Czapinska, Honorata and Poznańska, Anna and Shugar, David (2016) Halogen bonds involved in binding of halogenated ligands by protein kinases. Acta biochimica Polonica, 63 (2). pp. 203-214. ISSN 1734-154X
Data provider:
Repozytorium Instytutu Biochemii i Biofizyki Polskiej Akademii Nauk

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