Description

• Title:
  Calorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutions
• Creator:
  Urbaniak, Paweł;
  Buczkowski, Adam;
  Stepniak, Artur;
  Palecz, Bartłomiej
• Contributor:
  Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403, Lodz, Poland;
  Department of Biophysical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236, Lodz, Poland
• Description:
  Studies on the interactions between cucurbituril Q7 and gemcitabine (Gem) hydrochloride in water were carried out using isothermal titration calorimetry (ITC) and electrospray ionization–mass spectrometry (ESI-MS). According to ITC and ESI-MS, the formation of this complex occurs in both the solution containing excess gemcitabine and the solution containing excess cucurbituril Q7. ITC results confirm the formation of a thermodynamically stable supramolecular complex with stoichiometry 1:1. The inclusion mechanism of Gem inside the cucurbituril macromolecule is spontaneous (ΔG<0). This process is exothermic (ΔH<0) and is characterized by the loss of entropy (ΔS<0).;
  The study was financed from the Grant for Development of Young Researchers from the Faculty of Chemistry, University of Lodz, 2017.
• Object availability:
  free access
• Rights:
  Uznanie autorstwa 4.0 Międzynarodowe;
  http://creativecommons.org/licenses/by/4.0
• Date:
  2021.09.09;
  2018
• Type:
  Article
• Language:
  English
• Format:
  application/pdf
• Publisher:
  Springer Nature [Co-publication with Akadémiai Kiadó, Budapest, Hungary]
• Relation:
  Journal of Thermal Analysis and Calorimetry;134
• Subject:
  Cucurbituril Q7;
  CB[7;
  Gemcitabine hydrochloride;
  Isothermal titration calorimetry;
  Protonation constant of gemcitabine
• Identifier:
  Buczkowski, A., Stepniak, A., Urbaniak, P. et al. Calorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutions. J Therm Anal Calorim 134, 595–607 (2018). https://doi.org/10.1007/s10973-018-7295-7;
  1388-6150;
  http://hdl.handle.net/11089/39011 ;
  1588-2926;
  10.1007/s10973-018-7295-7
• Data provider:
  Repozytorium Uniwersytetu Łódzkiego
• Can I use it?:
  check license
• Type:
  image