Description

• Title:
  The Role of Gut Microbiota in Hypertension Management - A Review
• Creator:
  Kot, Alicja;
  Wojtczak, Marta;
  Myśliwiec, Natalia;
  Różycki, Adrian;
  Pniak, Michał;
  Miklis, Paweł;
  Mawlichanów, Maciej;
  Ciesielska, Aleksandra;
  Sieradzka, Aleksandra;
  Szerej, Krzysztof
• Description:
  Introduction and purpose: Hypertension, or high blood pressure, is a condition characterized by persistently elevatedarterial pressure, leading to severe complications such as heart disease, stroke, and kidneyfailure. According to the World Health Organization (WHO), hypertension affectsapproximately 1.13 billion people worldwide, contributing significantly to global morbidityand mortality. Emerging research has revealed a significant connection between gutmicrobiota—the diverse community of microorganisms residing in the gastrointestinaltract—and the regulation of blood pressure. This comprehensive review explores the intricaterelationship between gut microbiota and hypertension, delving into the underlyingmechanisms, evidence from animal and human studies, and potential therapeuticinterventions.The state of knowledge: Key mechanisms involved into regulation of blood pressure include the production of short-chain fatty acids (SCFAs), modulation of the renin-angiotensin system (RAS), immune system regulation, and metabolite production such as trimethylamine-N-oxide (TMAO). Animal studies using fecal microbiota transplantation (FMT) have provided strong evidencefor a causal role of gut microbiota in blood pressure regulation. Human studies have shownassociations between gut microbiota composition and hypertension, highlighting the potentialfor dietary interventions, probiotics, prebiotics, physical activity and FMT as therapeuticstrategies.Summary: This review underscores the promise of microbiota-targeted therapies in managinghypertension and calls for further research to elucidate precise mechanisms and developpersonalized medicine approaches. Understanding the complex interactions between gutmicrobiota and hypertension could pave the way for innovative treatments and improvedcardiovascular health outcomes.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2025 Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej
• Date:
  2025.02.10
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Quality in Sport; Tom 38 (2025); 57655;
  Quality in Sport; Vol. 38 (2025); 57655;
  2450-3118
• Format:
  application/pdf
• Publisher:
  University Center for Sports Research, Nicolaus Copernicus University, Torun, Poland
• Relation: https://apcz.umk.pl/QS/article/view/57655/41459
• Subject:
  hypertension;
  gut microbiota;
  short chain fatty acids;
  fecal microbiota transplantation;
  probiotics;
  trimethylamine-N-oxide;
  TMAO;
  physical activity;
  dietary interventions
• Identifier: https://apcz.umk.pl/QS/article/view/57655
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text