Description

• Title:
  The Impact of Obesity on Endometrial Cancer: A Comprehensive Analysis
• Creator:
  Kolano, Agata;
  Pejas, Anna;
  Markowiak, Szymon;
  Wardęszkiewicz, Marta;
  Jabłońska, Wiktoria;
  Kasprzak, Amelia;
  Świercz, Maciej;
  Truchta, Monika;
  Mańkowska, Aleksandra
• Description:
  Introduction and purpose: Endometrial cancer [EC] is the most common gynecological cancer in developed countries and its incidence is increasing worldwide. Obesity is a prominent risk factor associated with its incidence and progression. The aim of study: The article aims to provide a thorough explanation of the mechanisms through which obesity can contribute to the development of EC. Additionally, it emphasizes the crucial role of combating excess adipose tissue as a significant component of cancer prevention specifically targeting endometrial cancer. Material and method: ​​The literature review applied standard criteria and focused on PubMed articles using keywords: Endometrial cancer, Obesity, Mortality, Prevention, Pathogenesis Description of the State of Knowledge: Obesity significantly impacts EC development and prognosis, particularly in Type I cases. It modifies adipose tissue metabolism, affecting the release of various substances linked to tumor growth and mortality risk.The relative risks escalate with increasing BMI.  Following an EC diagnosis, higher BMI, especially ≥40, significantly associates with increased overall mortality risk. On a preventive front, exercise showcases its potential in reducing EC risk by moderating insulin and estrogen levels. Summary: These findings underscore the critical role of obesity in both EC development and prognosis, emphasizing the potential for preventive measures. Without proactive measures, the worldwide obesity epidemic will persist, exerting a substantial effect on EC occurrences.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2024 Agata Kolano, Anna Pejas, Szymon Markowiak, Marta Wardęszkiewicz, Wiktoria Jabłońska, Amelia Kasprzak, Maciej Świercz, Monika Truchta, Aleksandra Mańkowska
• Date:
  2024.01.09
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 51 (2024); 179-197;
  Journal of Education, Health and Sport; Tom 51 (2024); 179-197;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/47760/37350
• Subject:
  Endometrial cancer;
  Obesity;
  Obesity risk;
  Obesity mortality;
  Obesity prevention;
  Obesity pathogenesis
• Identifier: https://apcz.umk.pl/JEHS/article/view/47760
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text