Description

• Title:
  The Methods of Digging for “Gold” within the Salt: Characterization of Halophilic Prokaryotes and Identification of Their Valuable Biological Products Using Sequencing and Genome Mining Tools
• Twórca:
  Jęcz, Paulina;
  Lach, Jakub;
  Strapagiel, Dominik;
  Matera-Witkiewicz, Agnieszka;
  Stączek, Paweł
• Współtwórca:
  Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, 93-338 Lodz, Poland;
  Biobank Lab, Department of Molecular Biophysics, Faculty of Environmental Protection, University of Lodz, 93-338 Lodz, Poland;
  Screening Laboratory of Biological Activity Tests and Collection of Biological Material, Faculty of Pharmacy, Wroclaw Medical University, 50-368 Wroclaw, Poland;
  paulina.jecz@biol.uni.lodz.pl;
  Jakub.lach@biol.uni.lodz.pl;
  dominik.strapagiel@biol.uni.lodz.pl;
  agnieszka.matera-witkiewicz@umed.wroc.pl;
  pawel.staczek@biol.uni.lodz.pl
• Opis:
  Halophiles, the salt-loving organisms, have been investigated for at least a hundred years. They are found in all three domains of life, namely Archaea, Bacteria, and Eukarya, and occur in saline and hypersaline environments worldwide. They are already a valuable source of various biomolecules for biotechnological, pharmaceutical, cosmetological and industrial applications. In the present era of multidrug-resistant bacteria, cancer expansion, and extreme environmental pollution, the demand for new, effective compounds is higher and more urgent than ever before. Thus, the unique metabolism of halophilic microorganisms, their low nutritional requirements and their ability to adapt to harsh conditions (high salinity, high pressure and UV radiation, low oxygen concentration, hydrophobic conditions, extreme temperatures and pH, toxic compounds and heavy metals) make them promising candidates as a fruitful source of bioactive compounds. The main aim of this review is to highlight the nucleic acid sequencing experimental strategies used in halophile studies in concert with the presentation of recent examples of bioproducts and functions discovered in silico in the halophile’s genomes. We point out methodological gaps and solutions based on in silico methods that are helpful in the identification of valuable bioproducts synthesized by halophiles. We also show the potential of an increasing number of publicly available genomic and metagenomic data for halophilic organisms that can be analysed to identify such new bioproducts and their producers.;
  Publication’s printing cost was co-financed by the European Union from the European Social Fund under the "InterDOC-STARt" project (POWR.03.02.00-00-I033/16-00).
• Dostępność obiektu:
  free access
• Prawa:
  Uznanie autorstwa-Użycie niekomercyjne 4.0 Międzynarodowe;
  http://creativecommons.org/licenses/by-nc/4.0
• Data:
  2021.12.06;
  2021
• Typ:
  Article
• Język:
  English
• Format:
  application/pdf
• Wydawca:
  MDPI
• Relacja:
  Genes;12, 1756
• Temat i słowa kluczowe:
  halophiles;
  biomolecules;
  metagenomics;
  bioinformatics;
  genome mining;
  biodiversity;
  hypersaline environments
• Identyfikator:
  Lach, J.; Jęcz, P.; Strapagiel, D.; Matera-Witkiewicz, A.; Stączek, P. The Methods of Digging for “Gold” within the Salt: Characterization of Halophilic Prokaryotes and Identification of Their Valuable Biological Products Using Sequencing and Genome Mining Tools. Genes 2021, 12, 1756. https:// doi.org/10.3390/genes12111756;
  2073-4425;
  http://hdl.handle.net/11089/39971 ;
  10.3390/genes12111756
• Dostawca danych:
  Repozytorium Uniwersytetu Łódzkiego
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