Description

• Title:
  Review: proteins c-Myc and Myc-nick as potential targets for the melignant melanoma treatment
• Creator:
  Maryniuk, G.;
  Stepanov, G.;
  Oleynik, K.;
  Selyvanska, I.;
  Tereshchenko, L.;
  Dubna, Y.
• Description:
  Malignant melanoma is the most aggressive and life-threatening skin cancer with increasing incidences over the past decades. Despite accounting for only 4 % of all skin cancers, melanoma confers 80 % of skin cancer induced death. The underlying cause of melanoma progression and metastasis is poorly understood. Myc is a very strong proto-oncogene and it is very upregulated in many types of cancers. c-Myc protein is a transcription factor that activates expression of many genes. It drives cell proliferation, plays a very important role in regulating cell growth, apoptosis and differentiation. High c-Myc expression is associated with tumor metastasis and poor prognosis in human melanoma. Full-length c-Myc is converted into Myc-nick by calcium-dependent on cytosolic proteases that are members of the calpain family. In connection with the key role of the cytoplasmic protein Myc-nick in the autophagy activativation, increasing the resistance to chemotherapy and overall survival of tumor cells, it can be a target for treatment tumors under the conditions of c-Myc overexpression. That fact that the expression of Myc-nick increases the survival of cells after UV radiation can indicate the key role of the Myc-nick in tumorogenesis of melanoma cells.
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2023 G. Maryniuk, G. Stepanov, K. Oleynik, I. Selyvanska, L. Tereshchenko, Y. Dubna
• Date:
  2023.07.26
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 42 No. 1 (2023); 105-114;
  Journal of Education, Health and Sport; Tom 42 Nr 1 (2023); 105-114;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/45434/36184
• Subject:
  c-Myc;
  Myc-nick;
  autophagy;
  apoptosis;
  melanoma
• Identifier: https://apcz.umk.pl/JEHS/article/view/45434
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text