Description

• Title:
  The potential of naproxen and its derivatives in inhibiting the processes of initiation, promotion and progression of cancerogenesis
• Creator:
  Bednarz, Katarzyna;
  Banaś, Patryk;
  Sobańska, Natalia;
  Banasiak, Aleksandra;
  Teichman, Rafał;
  Kasprowicz, Jakub;
  Pierzchała, Jakub Rafał;
  Abram, Kamila;
  Adamus, Justyna;
  Hyjek, Michał
• Description:
  Introduction: Naproxen is a non-steroidal anti-inflammatory drug mainly used to treatinflammation, pain, and fever of various etiology. Scientific studies conducted over the lastfive years have shown, that its introduction significantly influenced neoplastic processes inthe in vitro and in vivo studies carried out within cell cultures and animal models.Aim of the study: Our aim was to review the theses, extract and present the influence ofnaproxen and its derivatives in signaling pathways involved in the initiation, promotion andprogression of cancer as well as to indicate potential directions for further research.Methods and materials: We have reviewed the theses in the bibliographic PubMed database,using the keywords: „naproxen”; „naproxen derivatives”; „cancer”; „cancer treatment”„cancer prevention”.Results: In addition to the well-known mechanism of inhibiting COX, there are scientificproofs of the activity of naproxen against other molecules, such as PI3-K(phosphatidylinositol 3-kinase), GSK-3β (glycogen synthase kinase-3β), NFκB (nucleartranscription factor κB), MMP ( metalloproteinases), NO (nitric oxide) involved in neoplasticprocesses.Conclusion: Conclusions drawn from the analysis of specific molecular activities of naproxenand its derivatives against neoplastic processes are promising. However, more preclinicalresearch is needed to confirm the effectiveness, practical applicability and to assess the sideeffects of the therapy, before starting the clinical trials in humans.
• Object availability:
  free access
• Rights:
  Prawa autorskie (c) 2022 Katarzyna Bednarz, Patryk Banaś, Natalia Sobańska, Aleksandra Banasiak, Rafał Teichman, Jakub Kasprowicz, Jakub Rafał Pierzchała, Kamila Abram, Justyna Adamus, Michał Hyjek;
  https://creativecommons.org/licenses/by-nc-sa/4.0
• Date:
  2022.10.22
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 12 No. 11 (2022); 103-108;
  Journal of Education, Health and Sport; Tom 12 Nr 11 (2022); 103-108;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/40527/33527
• Subject:
  naproxen;
  naproxen derivatives;
  cancer;
  cancer treatment;
  cancer prevention
• Identifier: https://apcz.umk.pl/JEHS/article/view/40527
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text