Description

• Title:
  Targeted therapy with histamine antagonists - New challenges to fight with breast cancer
• Creator:
  Więsyk, Piotr Jan;
  Oleksa, Paulina;
  Chilimoniuk, Zuzanna;
  Dobosz, Maciej;
  Sobczyk, Maciej;
  Słaboń, Małgorzata
• Description:
  Breast cancer (BC) is currently the most commonly diagnosed cancer in women. BC is most often derived from the epithelial tissue of the mammary gland and is a global problem due to the steady increase in morbidity and mortality in most countries. A particular problem today is the triple negative subtype (TNBC), which accounts for approximately 10-15% of breast cancer cases. BC occurs most frequently in young women and is characterised by various biological characteristics, an unfavourable clinical course and a poor prognosis. Recent studies to detect the effects of histamine receptors on breast cancer have shown that all H1R-H4R receptors are also hyperactive in the cancer microenvironment. Chronically maintaining a high level of histamine in the tumour-affected tissue contributes to increased angiogenesis at this site, induction of cancer cells proliferation and T lymphocyte dysfunction. The rising incidence of breast cancer is contributing to an increasing amount of research into targeted therapies. Studies on the effect of histamine antagonists through H1R-H4R receptors have proven their effectiveness in the treatment of breast cancer. Among those in the study, there was a reduction in tumour growth, cell proliferation and an increase in apoptosis. The use of histamine antagonists also contributed to a reduced risk of death from breast cancer and increased overall survival (OS). Therefore, targeted therapy is needed to improve the prognosis of patients with breast cancer. 
• Object availability:
  free access
• Rights: https://creativecommons.org/licenses/by-nc-sa/4.0 ;
  Prawa autorskie (c) 2022 Piotr Jan Więsyk, Paulina Oleksa, Zuzanna Chilimoniuk, Maciej Dobosz, Maciej Sobczyk, Małgorzata Słaboń
• Date:
  2022.11.15
• Type:
  info:eu-repo/semantics/article;
  info:eu-repo/semantics/publishedVersion
• Language:
  English
• Source:
  Journal of Education, Health and Sport; Vol. 12 No. 12 (2022); 87-93;
  Journal of Education, Health and Sport; Tom 12 Nr 12 (2022); 87-93;
  2391-8306
• Format:
  application/pdf
• Publisher:
  Nicolaus Copernicus University, Toruń, Poland
• Relation: https://apcz.umk.pl/JEHS/article/view/40145/33703
• Subject:
  Histamine;
  Histamine Receptors;
  Breast cancer
• Identifier: https://apcz.umk.pl/JEHS/article/view/40145
• Data provider:
  Akademicka Platforma Czasopism
• Can I use it?:
  seek permission
• Type:
  text